Evidence map›Paper›PMID 42321026›Full record

ArticleTrends in cell biology2026

Crashing by design: Utilizing DNA damage for MCC differentiation.

Eve E Suva, Brian J Mitchell

Abstract read
In one paragraph

Article in Trends in cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Eve E SuvaDepartment of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Brian J MitchellDepartment of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address: brian-mitchell@northwestern.edu.

Funding

Identification and characterization of novel genes causative for primary ciliary dyskinesiaR01HL173147 · NHLBI · NORTHWESTERN UNIVERSITY · PI BRIAN Joseph MITCHELL · 2025 to 2026
$1.5M
NHLBI NIH HHS R01 HL173147
6 · The paper itself

Abstract

Multiciliated cells (MCCs) represent a complex cell type with a range of unique features. Jewett et al. identify a novel DNA damage response (DDR) that occurs during MCC differentiation. Inhibition of DDR blocks the formation of MCCs, indicating that this damage response is likely an important step in MCC differentiation.

Indexed as

Cell DifferentiationCiliaDNA DamageAnimalsHumanscell cycledifferentiationDNA damagemulticiliated cells

Identifiers

PMID42321026
PMCPMC13286232

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.