ArticleNature communications2026
Neuron-targeting piezoelectric microneedles disrupt pro-tumorigenic neuron-immune crosstalk and restore anti-tumor immunity in melanoma.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroimmunology has garnered significant attention due to its role in immune regulation, particularly in cancer, where infiltrating neurons can influence antigen presentation, T-cell activation, and cancer metastasis, ultimately leading to an inadequate immune response. Here, we integrate manganese-doped titanium-based metal-organic framework (MOF) piezoelectric materials (MT), coated with neuron-derived membranes from dorsal root ganglia, into microneedles (MN) to create a piezoelectric microneedle (MT MN) patch designed to disrupt neuron-immune crosstalk in melanoma. A single administration of MT via microneedle patch stably deposits the MT at the melanoma site in female mice to accelerate the nociceptor neurons targeting. Upon moderate ultrasound stimulation, the MT facilitates the internalization of TRPV1 and activates the cGAS-STING pathway, resulting in the reduction of Ca
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.