Evidence map›Paper›PMID 42321267›Full record

ArticleScientific reports2026

Hyperlipidemia induces hippocampal inflammation and loss of vascularity and can be rescued by silencing RIPK1.

Jonathan Salazar-Leon, Moises Freitas-Andrade, Violeta Guadarrama-Perez, Serena Solari, Abagael Hudak, Cameron Stotts, Nancy Simon, Michèle Geoffrion, Sue Murray, Ruth Slack and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jonathan Salazar-LeonUniversity of Ottawa Heart Institute, Ottawa, ON, Canada.
Moises Freitas-AndradeOttawa Hospital Research Institute, Ottawa, ON, Canada.
Violeta Guadarrama-PerezUniversity of Ottawa Heart Institute, Ottawa, ON, Canada.
Serena SolariUniversity of Ottawa Heart Institute, Ottawa, ON, Canada.
Abagael HudakUniversity of Ottawa Heart Institute, Ottawa, ON, Canada.
Cameron StottsUniversity of Ottawa Heart Institute, Ottawa, ON, Canada.
Nancy SimonUniversity of Ottawa Heart Institute, Ottawa, ON, Canada.
Michèle GeoffrionUniversity of Ottawa Heart Institute, Ottawa, ON, Canada.
Sue MurrayIonis Pharmaceuticals, Carlsbad, CA, USA.
Ruth SlackUniversity of Ottawa Heart Institute, Ottawa, ON, Canada.
Baptiste LacosteOttawa Hospital Research Institute, Ottawa, ON, Canada.
Katey J RaynerUniversity of Ottawa Heart Institute, Ottawa, ON, Canada. KRayner@ottawaheart.ca.

Funding

Canada First Research Excellence Fund Brain-Heart Interconnectome
6 · The paper itself

Abstract

Vascular cognitive impairment (VCI) is a common form of dementia associated with cerebrovascular dysfunction and chronic inflammation. Impaired cerebral perfusion is a result of atherosclerotic plaque build-up in the medium and large arteries in the brain and is exacerbated by numerous inflammatory triggers, including aging, high blood pressure, high cholesterol, and smoking. Previously, we demonstrated that receptor-interacting protein 1 kinase (RIPK1) promotes the progression of aortic atherosclerosis and NFκB activation in mice, and that atherosclerotic vascular disease was decreased by therapeutically inhibiting RIPK1 with antisense oligonucleotides. Given the relationship between atherosclerosis and cognitive impairment, we hypothesize that RIPK1 also contributes to the development of cerebrovascular disease and neuroinflammation in a mouse model of hyperlipidemia. Male and female Apoe

Indexed as

HippocampusHyperlipidemiasInflammationReceptor-Interacting Protein Serine-Threonine KinasesAnimalsCerebrovascular CirculationDisease Models, AnimalFemaleGene SilencingMaleMiceMice, Inbred C57BLOligonucleotides, AntisenseOligonucleotides, AntisenseReceptor-Interacting Protein Serine-Threonine KinasesRipk1 protein, mouseAntisense oligonucleotidesCardiovascular diseasesKnockdownNeurovascular unitReceptor-interacting protein 1 kinaseVascular cognitive impairment

Identifiers

PMID42321267
PMCPMC13558570

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.