Evidence map›Paper›PMID 42321514›Full record

ArticleEye (London, England)2026

Spatial distribution of cuticular drusen and its association with category-specific progression risk in intermediate AMD.

Jianfeng Huang, Muneeswar Gupta Nittala, Giulia Corradetti, Yu-Chien Chung, Alberto Quarta, Rouzbeh Abbasgholizadeh, Ceren Soylu, Shinichiro Chujo, Swetha Bindu Velaga, Srinivas R Sadda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Eye (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Jianfeng HuangDoheny Eye Institute, Pasadena, CA, USA.ORCID http://orcid.org/0000-0002-4576-2581
Muneeswar Gupta NittalaDoheny Eye Institute, Pasadena, CA, USA.
Giulia CorradettiDoheny Eye Institute, Pasadena, CA, USA.
Yu-Chien ChungDepartment of Ophthalmology, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City, Taiwan.ORCID http://orcid.org/0000-0003-4745-8601
Alberto QuartaDoheny Eye Institute, Pasadena, CA, USA.
Rouzbeh AbbasgholizadehDoheny Eye Institute, Pasadena, CA, USA.
Ceren SoyluDoheny Eye Institute, Pasadena, CA, USA.
Shinichiro ChujoDoheny Eye Institute, Pasadena, CA, USA.
Swetha Bindu VelagaDoheny Eye Institute, Pasadena, CA, USA.ORCID http://orcid.org/0000-0002-4637-6914
Srinivas R SaddaDoheny Eye Institute, Pasadena, CA, USA. ssadda@doheny.org.ORCID http://orcid.org/0000-0002-4939-3306

Funding

Genetic Epidemiology of Age-Related Macular Degeneration in the Older Order AmishR01EY023164 · NEI · UNIVERSITY OF PENNSYLVANIA · PI PERICAK-VANCE, MARGARET A., STAMBOLIAN, DWIGHT EDWARD · 2013 to 2017
$6.2M
Epidemiology of Biomarkers of AMD ProgressionR01EY030614 · NEI · DOHENY EYE INSTITUTE · PI Jonathan L Haines, Margaret A. Pericak-Vance · 2021 to 2026
$3.0M
NEI NIH HHS R01 EY023164NEI NIH HHS R01 EY030614U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI) 1R01EY030614U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI) RO1EY023164
6 · The paper itself

Abstract

objectivesTo investigate the spatial distribution pattern of cuticular drusen using en face OCT and determine its relationship with 2-year progression of age-related macular degeneration (AMD).

methodsThis study included 87 eyes from 57 participants with intermediate AMD and cuticular drusen enroled in the Amish Eye Study who completed two years of follow-up. Multimodal imaging, including volume spectral-domain OCT, was performed. Density of cuticular drusen was quantified on en face OCT across three Early Treatment Diabetic Retinopathy Study (ETDRS) grid zones using ImageJ. K-means clustering analysis was used to categorize distribution patterns. Firth's penalized logistic regression evaluated association between cuticular drusen distribution categories and progression to late AMD at 2 years.

resultsThree spatial phenotypes of cuticular drusen were identified: central-dominant (57.5%), outer-macular-dominant (32.2%), and diffuse (10.3%). Over two years, five eyes progressed to late AMD, four of which belonged to the outer-macular-dominant group. In unadjusted Firth regression, the outer-macular-dominant phenotype was associated with higher odds of progression than the other phenotypes (OR 7.16; 95% CI 1.24-74.20, p = 0.027). After adjustment for subretinal drusenoid deposits (SDDs) and large drusen, the association between spatial phenotype and progression remained (OR 11.53; 95% CI 1.62-169.00; p = 0.013), while SDDs were also associated with progression (OR 9.26; 95% CI 1.36-78.65; p = 0.023).

conclusionsClustering of en face OCT-derived spatial features identified distinct cuticular drusen phenotypes within the macula. The outer-macular-dominant phenotype may be associated with an increased likelihood of AMD progression in this exploratory analysis.

Indexed as

Macular DegenerationRetinal DrusenAgedAged, 80 and overBruch MembraneDisease ProgressionEye Diseases, HereditaryFemaleFollow-Up StudiesHumansMaleMiddle AgedRisk FactorsTomography, Optical Coherence

Identifiers

PMID42321514
PMCPMC13533437

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.