Evidence map›Paper›PMID 42323371›Full record

ArticleScientific reports2026

Dual engagement of Spike and ACE2 by annexin A5 contributes to pleiotropic SARS-CoV-2 inhibition.

Arundhasa Chandrabalan, Qi-Tong Lin, Khandaker Atkia Fariha, Paul Solis-Reyes, Connor G Richer, Ryan M Troyer, Stephen D Barr, Qingping Feng, Peter B Stathopulos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Arundhasa ChandrabalanDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 5C1, Canada.
Qi-Tong LinDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 5C1, Canada.
Khandaker Atkia FarihaDepartment of Microbiology & Immunology, University of Western Ontario, London, ON, N6A 5C1, Canada.
Paul Solis-ReyesDepartment of Microbiology & Immunology, University of Western Ontario, London, ON, N6A 5C1, Canada.
Connor G RicherDepartment of Microbiology & Immunology, University of Western Ontario, London, ON, N6A 5C1, Canada.
Ryan M TroyerDepartment of Microbiology & Immunology, University of Western Ontario, London, ON, N6A 5C1, Canada. rtroyer@uwo.ca.
Stephen D BarrDepartment of Microbiology & Immunology, University of Western Ontario, London, ON, N6A 5C1, Canada. sbarr9@uwo.ca.
Qingping FengDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 5C1, Canada. qfeng@uwo.ca.
Peter B StathopulosDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 5C1, Canada. pstatho@uwo.ca.ORCID https://orcid.org/0000-0002-0536-6656

Funding

CIHR 178398
6 · The paper itself

Abstract

COVID-19 is primarily a respiratory tract infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which can enter host airway epithelial cells through angiotensin-converting enzyme 2 (ACE2) receptors. Emerging SARS-CoV-2 variants are a roadblock to irradicating the disease. Given recombinant human annexin A5 (Anx5) inhibits proinflammatory responses, improves survival in sepsis models and binds to several receptors and lipids, we hypothesized that Anx5 impedes SARS-CoV-2 viral entry and lessens disease severity. To assess SARS-CoV-2 Spike-receptor binding domain (RBD) and ACE2 interactions with Anx5, the recombinant proteins were expressed and isolated, and interactions were evaluated using solution NMR, microscale thermophoresis, steady-state fluorescence and size-exclusion chromatography coupled to multi-angle light scattering. Remarkably, we found that Anx5 binds to both the Spike-RBD and ACE2. Further, Anx5 induced extensive

Indexed as

Angiotensin-Converting Enzyme 2Annexin A5COVID-19SARS-CoV-2Spike Glycoprotein, CoronavirusAnimalsHumansProtein BindingRecombinant ProteinsVirus InternalizationACE2 protein, humanAngiotensin-Converting Enzyme 2Annexin A5Recombinant ProteinsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2ACE2Annexin A5COVID-19SARS-CoV-2Spike-RBD

Identifiers

PMID42323371
PMCPMC13558681

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.