ReviewAesthetic plastic surgery2026
Platelet-Rich Plasma: An Endogenous Bioregulatory Modulator Coordinating Soft Tissue Remodeling.
Review in Aesthetic plastic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundPlatelet-rich plasma (PRP) has emerged as a major focus in soft-tissue repair in recent years, with its diverse biological functions supported by extensive experimental and clinical evidence. The biological activity of PRP extends beyond simple growth-factor delivery and is shaped by preparation heterogeneity.
methodsThis review synthesized English-language evidence from PubMed/MEDLINE, Web of Science, and Google Scholar on PRP, platelet-rich fibrin, platelet-derived extracellular vesicles, soft-tissue repair, scarring, fibrosis, angiogenesis, macrophage polarization, mitochondrial transfer, stem/progenitor cells, adipose grafting, facial rejuvenation, and aesthetic soft-tissue remodeling, with literature considered up to March 2026.
resultsCurrent evidence indicates that PRP may influence several stages of soft-tissue remodeling, including inflammatory and immune regulation, angiogenesis and redox balance, extracellular matrix deposition and degradation, and endogenous tissue regeneration. Mechanistic findings link these effects to macrophage phenotypic modulation, TGF-β/Smad signaling, vascular reconstruction, matrix metalloproteinase activity, mitochondrial transfer, and regulation of tissue-resident stem or progenitor cells. However, PRP is not a single standardized biological product; platelet concentration, leukocyte content, activation method, fibrin architecture, release kinetics, delivery route, and distinctions among conventional PRP, PRF, and PRP-derived extracellular vesicles may substantially affect biological behavior and clinical interpretation.
conclusionsPRP may be best understood as a context-dependent, platelet-derived bioregulatory system that modifies the local tissue microenvironment rather than as a simple volumizing or growth-factor supplement. Its potential relevance to scar revision, fat-graft retention, wound-related contour irregularity, post-inflammatory stiffness, and facial rejuvenation supports further standardized clinical studies with clearly reported formulations and outcomes. LEVEL OF EVIDENCE III: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
Indexed as
Identifiers
42323446What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.