Evidence map›Paper›PMID 42323686›Full record

ArticleAlzheimer's research & therapy2026

Myelin-driven structural network redundancy underlies cognition in cerebral small vessel disease.

Yage Qiu, Wentao Hu, Yao Wang, Qingyang Fu, Ying Hu, Qun Xu, Hongjiang Wei, Yan Zhou, Yawen Sun

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Article in Alzheimer's research & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

9 authors.

Yage Qiu *Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160 Pujian Rd, Pudong New District, Shanghai, 200127, China.
Wentao Hu *Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160 Pujian Rd, Pudong New District, Shanghai, 200127, China.
Yao Wang *Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160 Pujian Rd, Pudong New District, Shanghai, 200127, China.
Qingyang FuDepartment of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160 Pujian Rd, Pudong New District, Shanghai, 200127, China.
Ying HuDepartment of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160 Pujian Rd, Pudong New District, Shanghai, 200127, China.
Qun XuDepartment of Neurology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160 Pujian Rd, Pudong New District, Shanghai, 200127, China.
Hongjiang WeiSchool of Biomedical Engineering, Shanghai Jiao Tong University, No. 800 Dongchuan Rd, Minhang District, Shanghai, 200240, China.
Yan ZhouDepartment of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160 Pujian Rd, Pudong New District, Shanghai, 200127, China. clare1475@hotmail.com.
Yawen SunDepartment of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160 Pujian Rd, Pudong New District, Shanghai, 200127, China. cjs1119@hotmail.com.

Funding

Eastern Talent Plan Leading Project LJ2023127Leading Talent Program of Shanghai Municipal Health Commission 2022LJ023National Natural Science Foundation of China 82171885National Natural Science Foundation Promotion Project of Ren Ji Hospital RJTJ25-MS-110Shanghai Science and Technology Committee Project 24TS1414800Shanghai YRD Foundation for Innovation in Health Industry 2025-YRDFHI-086
6 · The paper itself

Abstract

backgroundWhite matter hyperinxtensity (WMH) and normal-appearing white matter (NAWM) are critical markers for tracking disease progression in cerebral small vessel disease (CSVD), indicative of a spectrum of white matter injury. The core pathological alteration underlying such injury is the disruption of myelin integrity and loss of axons. We hypothesized that the myelin content in WMH and NAWM may exert distinct effects on brain networks and cognition in CSVD.

methodsA total of 129 diagnosed CSVD patients were retrospectively enrolled. Myelin content was assessed with sub-voxel precision using iterAtive magnetic suscePtibility sources sepARaTion Quantitative Susceptibility Mapping (APART-QSM). Structural network redundancy was derived from diffusion tensor imaging (DTI). WMH and NAWM masks were generated. Associations between WMH/NAWM myelin content, structural network redundancy, and cognitive performance were examined using partial correlation and mediation analyses.

resultsMyelin content was significantly higher in NAWM than in WMH. Decreased structural network redundancy was significantly linked to myelin loss in NAWM but not in WMH. Moreover, redundancy indirectly linked NAWM myelin to cognition, whereas no such indirect pathway was observed for WMH myelin. No direct or total effect of myelin content on cognition was observed.

conclusionsThese findings highlight the critical role of NAWM-related myelin integrity in preserving cognition through its association with structural network redundancy in CSVD.

Indexed as

BrainCerebral Small Vessel DiseasesCognitionMyelin SheathWhite MatterAgedDiffusion Tensor ImagingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsRetrospective StudiesCerebral small vessel diseaseCognitionMyelinNormal-appearing white matterStructural network redundancy

Identifiers

PMID42323686

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.