Observational studyPediatric pulmonology2026
Ventilation Intensity and Prognosis in Pediatric Oncology: Mechanical Power, Compliance, and Mortality Risk.
Observational study in Pediatric pulmonology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMechanical power (MP) and dynamic compliance (Cdyn) are key determinants of ventilator-induced lung injury (VILI) and mortality. This study aimed to identify variables associated with MP and Cdyn and evaluate their impact on mortality and ventilator-free days (VFD) in critically ill children with cancer.
methodsWe conducted a prospective, observational study of 57 patients. Multivariate logistic regression and competing risk models were applied to assess predictors of mortality and VFD.
resultsThe median age was 69 months, with a median of three organ dysfunctions. Mechanical power normalized by dynamic compliance (MP/Cdyn) emerged as an independent predictor of mortality across multivariable models: MP/Cdyn was significantly associated with death alongside the number of organ dysfunctions (OR: 5.44, 95% CI: 1.78-18.6, p = 0.003; OR: 1.62, 95% CI: 1.07-2.47, p = 0.023), platelet count <30,000/μL (OR: 4.23, 95% CI: 1.36-13.1, p = 0.013; OR: 4.92, 95% CI: 1.31-18.4, p = 0.018), and renal and immunologic dysfunctions. ROC analysis of MP/Cdyn for ICU mortality yielded an AUC of 0.76, with a cutoff of 1.11 J·cmH
conclusionsIn critically ill children with cancer, elevated mechanical power is strongly linked to reduced ICU survival and fewer VFD. These findings highlight the prognostic importance of ventilation strategies in this vulnerable population.
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