Differential motor unit firing rate and hypertrophic adaptations of the vastus lateralis despite similar strength increases following high-load versus combined high- and low-load resistance training interventions.

Alex A Olmos, Daniel J Lawson, Stephanie A Sontag, Lyric D Richardson, Brenden L Roth, Sunggun Jeon, Allen L Redinger, Sean M Gamache, Michael A Trevino

Abstract read

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In one paragraph

Article in Experimental brain research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alex A OlmosDepartment of Molecular Biology and Chemistry, Christopher Newport University, Newport News, VA, 23606, US.

Daniel J LawsonFitomics, Alabaster, AL, 36849, US.

Stephanie A SontagSchool of Kinesiology, Louisiana State University, Baton Rouge, LA, 70803, US.

Lyric D RichardsonApplied Neuromuscular Physiology Laboratory, Department of Health and Human Performance, Oklahoma State University, 191 CRC, Stillwater, OK, 47074, US.

Brenden L RothApplied Neuromuscular Physiology Laboratory, Department of Health and Human Performance, Oklahoma State University, 191 CRC, Stillwater, OK, 47074, US.

Sunggun JeonDepartment of Health and Human Performance, Northwestern State University, Natchitoches, LA, 71497, US.

Allen L RedingerNeuromuscular Research Laboratory/Warrior Human Performance Research Center, University of Pittsburgh, Pittsburgh, PA, 15203, US.

Sean M GamacheDepartment of Molecular Biology and Chemistry, Christopher Newport University, Newport News, VA, 23606, US.

Michael A TrevinoApplied Neuromuscular Physiology Laboratory, Department of Health and Human Performance, Oklahoma State University, 191 CRC, Stillwater, OK, 47074, US. michael.a.trevino@okstate.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While the role of resistance training-induced muscle hypertrophy on early strength gains is still debated, it is unclear whether the specificity of training, such as high-load (H) training for increasing strength, results in different motor unit (MU) adaptations than combined high- and low-load (H + L) training for increasing strength and hypertrophy. Therefore, this study examined the effects of six weeks of either H- or H + L-training on leg press 1-repetition maximum (1-RM), isometric knee extensor strength via maximal voluntary contraction (MVC), and muscle cross-sectional area (mCSA) and MU behavior of the vastus lateralis (VL) in untrained males that were pseudorandomized into a H (n = 18), H + L (n = 17), or a control group (n = 11). Surface electromyographic (sEMG) signals for a 40% MVC were recorded from the VL and decomposed for analysis of MU: recruitment thresholds (RTs), action potential amplitudes (MUAP

Indexed as

Action PotentialsAdaptation, PhysiologicalMotor NeuronsMuscle StrengthQuadriceps MuscleRecruitment, NeurophysiologicalResistance TrainingAdultElectromyographyHumansIsometric ContractionMaleYoung AdultMotor unitMuscle hypertrophyResistance trainingVastus lateralis

Identifiers

PMID42323749

DOI10.1519/JSC.0000000000001049

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.