Evidence map›Paper›PMID 42323772›Full record

ArticleWorld journal of urology2026

Finding a solution: preliminary results of percutaneous nephrolithotomy outcomes under saline-restricted irrigation conditions.

Tyler Lunow-Luke, Tom No, Aymon Ali, Bruce M Gao, Jonathan Badin-Castro, Seyed Amiryaghoub Lavasani, Pengbo Jiang, Jaime Landman, Ralph V Clayman, Roshan M Patel

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Article in World journal of urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Tyler Lunow-LukeDepartment of Urology, University of California, Irvine, 3800 W. Chapman Ave, Suite 7200, Orange, CA, 92868, USA.
Tom NoDepartment of Urology, University of California, Irvine, 3800 W. Chapman Ave, Suite 7200, Orange, CA, 92868, USA.
Aymon AliDepartment of Urology, University of California, Irvine, 3800 W. Chapman Ave, Suite 7200, Orange, CA, 92868, USA.
Bruce M GaoDepartment of Urology, University of California, Irvine, 3800 W. Chapman Ave, Suite 7200, Orange, CA, 92868, USA.
Jonathan Badin-CastroDepartment of Urology, University of California, Irvine, 3800 W. Chapman Ave, Suite 7200, Orange, CA, 92868, USA.
Seyed Amiryaghoub LavasaniDepartment of Urology, University of California, Irvine, 3800 W. Chapman Ave, Suite 7200, Orange, CA, 92868, USA.
Pengbo JiangDepartment of Urology, University of California, Irvine, 3800 W. Chapman Ave, Suite 7200, Orange, CA, 92868, USA.
Jaime LandmanDepartment of Urology, University of California, Irvine, 3800 W. Chapman Ave, Suite 7200, Orange, CA, 92868, USA.
Ralph V ClaymanDepartment of Urology, University of California, Irvine, 3800 W. Chapman Ave, Suite 7200, Orange, CA, 92868, USA.
Roshan M PatelDepartment of Urology, University of California, Irvine, 3800 W. Chapman Ave, Suite 7200, Orange, CA, 92868, USA. roshanmp@hs.uci.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn September 2024, flooding from Hurricane Helene shut down a Baxter Solutions facility, which produced ~ 60% of the United States' intravenous fluids, resulting in a nationwide saline shortage. Hospitals subsequently restricted perioperative irrigation, including in percutaneous nephrolithotomy (PCNL), which traditionally relies on continuous saline irrigation throughout the procedure. We compared outcomes of PCNL under saline-restricted conditions with matched cases performed before the shortage.

methodsBetween October 15 and November 4, 2024, ten PCNLs were performed with recommendations to minimize irrigation. A matched control group was selected from a prospective institutional PCNL database, matched by age, sex, stone size, and operative time. Perioperative and postoperative outcomes-including irrigation volume, stone-free rate, laboratory values, and hospital length of stay-were analyzed using t-tests, Pearson chi-square, and Fisher's exact tests.

resultsMean irrigation volume was significantly lower in the saline-restricted group compared with controls (6,600 ± 4,852 mL vs. 19,125 ± 18,195 mL, p = 0.009). There were no significant differences in baseline demographics, stone volume, or operative time. The saline-restricted group had a shorter hospital length of stay (0.9 ± 0.3 days vs. 1.8 ± 1.8, p = 0.0462), and lower postoperative day 1 creatinine (0.9 ± 0.3 mg/dL vs. 1.3 ± 0.5 mg/dL, p = 0.026). Postoperative hemoglobin, hematocrit, residual stone burden, and residual stone grades were similar between groups.

conclusionPCNL performed under saline-restriction significantly reduced irrigation volume without adversely affecting early postoperative outcomes or residual stone burden. These findings support judicious saline use during PCNL, particularly in times of supply shortage.

Indexed as

Kidney CalculiNephrolithotomy, PercutaneousSaline SolutionTherapeutic IrrigationFemaleHumansLength of StayMaleTreatment OutcomeSaline SolutionHurricane heleneIntravenous fluid supply disruptionIrrigation volumePercutaneous nephrolithotomyPerioperative outcomesSaline shortage

Identifiers

PMID42323772

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.