Evidence map›Paper›PMID 42324264›Full record

ArticleNature communications2026

Mitochondrial DNA heteroplasmy drives cortical neuronal disturbances in human organoids harbouring the common m.3243A>G mutation.

Denisa Hathazi, Camilla Lyons, Daniel Lagos, Oliver Podmanicky, Mariana Zarate-Mendez, Yu Nie, Juliane S Müller, Kieren S J Allinson, Huw Naylor, Majlinda Lako and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Denisa HathaziDepartment of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, UK. gdh29@cam.ac.uk.
Camilla LyonsMRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
Daniel LagosDepartment of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-2609-5397
Oliver PodmanickyDepartment of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, UK.
Mariana Zarate-MendezDepartment of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, UK.
Yu NieMRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
Juliane S MüllerDepartment of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, UK.
Kieren S J AllinsonDepartment of Histopathology, Cambridge University Hospital, Cambridge, UK.
Huw NaylorLight Microscopy Core, Cancer Research Cambridge Institute, Cambridge, UK.ORCID http://orcid.org/0000-0001-8264-8596
Majlinda LakoBiosciences Institute, Newcastle University, Newcastle, UK.ORCID http://orcid.org/0000-0003-1327-8573
Ibrahim ElsharkawiDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, USA.
Irena MuffelsDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, USA.
Eva MoravaDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, USA.
Tamas KoziczDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, USA.ORCID http://orcid.org/0000-0001-6915-4364
Patrick ChinneryMRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-7065-6617
András Lakatos *Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, UK. al291@cam.ac.uk.
Rita Horvath *Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, UK. rh732@medschl.cam.ac.uk.ORCID http://orcid.org/0000-0002-9841-170X

Funding

Wellcome Trust (Wellcome) 226653/Z/22/Z
6 · The paper itself

Abstract

Mitochondrial diseases frequently affect the brain leading to severe and disabling neurological symptoms. The heteroplasmic m.3243 A > G mutation in MT-TL1, encoding mt-tRNA

Indexed as

Cerebral CortexDNA, MitochondrialHeteroplasmyNeuronsOrganoidsRNA, Transfer, LeuApoptosisHumansInduced Pluripotent Stem CellsMELAS SyndromeMitochondriaMitochondrial DiseasesMutationDNA, MitochondrialMT-TL1 tRNA, humanRNA, Transfer, Leu

Identifiers

PMID42324264
PMCPMC13438594

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.