Evidence map›Paper›PMID 42324338›Full record

ArticlePediatric research2026

Serum inflammatory and metabolic signatures accelerate precocious puberty in obese children.

Li Wang, Heqiu Yan, Jun Liu, Jing Zhang, Xinran Cheng, Haibo Yao, Fang Tang, Mengjun Luo

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Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Li Wang *Reproductive Medicine Center, Key Laboratory of Reproductive Medicine, Sichuan Provincial Maternity and Child Health Care Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, China.
Heqiu Yan *Reproductive Medicine Center, Key Laboratory of Reproductive Medicine, Sichuan Provincial Maternity and Child Health Care Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, China.
Jun Liu *Reproductive Medicine Center, Key Laboratory of Reproductive Medicine, Sichuan Provincial Maternity and Child Health Care Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, China.
Jing ZhangDepartment of Endocrine Genetics and Metabolism, School of Medicine, Chengdu Women's and Children's Center Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Xinran ChengDepartment of Endocrine Genetics and Metabolism, School of Medicine, Chengdu Women's and Children's Center Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Haibo YaoDepartment of Medical Records, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Fang TangDepartment of Endocrine Genetics and Metabolism, School of Medicine, Chengdu Women's and Children's Center Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Mengjun LuoDepartment of Clinical Laboratory, Chengdu Women's and Children's Center Hospital. School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. 462816877@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to characterize the interplay of metabolic, hormonal, and inflammatory factors in precocious puberty and obesity.

methodsThis cross-sectional study enrolled 417 children were included Control (n = 97), Obesity (n = 102), Central Precocious Puberty (CPP, n = 103), and obesity with precocious puberty group (OPP, n = 115) groups. Basic anthropometric, hormonal, metabolic, and inflammatory indicators were analyzed. Group comparisons were performed using ANOVA/Kruskal-Wallis tests. Receiver operating characteristic (ROC) curve was applied to assess biomarkers for predicting precocious puberty in obese children, and Spearman correlation evaluated biomarker relationships.

resultsBone age advancement and elevated levels of LH, FSH, and IGF-1 were observed in both the CPP and OPP group compared to the Controls. ROC curve indicated that IGF-1 had high predictive value (AUC = 0.810) for precocious puberty in obese children. The Obesity and OPP groups exhibited significantly elevated triglycerides, liver enzymes (GGT, ALT), and inflammatory indices (NLR, WBC) relative to the CPP group. OPP correlated positively with LH, FSH, TC, NLR, and IGF-1.

conclusionObesity-associated precocious puberty involves concurrent elevations in hormonal, metabolic, and inflammatory biomarkers. Clinical management of pubertal disorders in children with obesity should incorporate integrated assessment of inflammatory and metabolic dysregulation alongside endocrine markers. IMPACT: It provides comparative evidence that the obesity-associated precocious puberty exhibits a more severe metabolic and inflammatory profile than the Central Precocious Puberty without obesity, suggesting obesity exacerbates these dysregulations alongside puberty timing. The findings strongly argue that clinical management of precocious puberty in obese children requires an integrated approach, assessing not just hormonal markers but also metabolic health and inflammation for comprehensive evaluation. It underscores the complex interplay and potential shared mechanisms between metabolic dysfunction, inflammation, and the hormonal activation of puberty, emphasizing the need for future research to investigate these interconnected pathways in pediatric endocrine disorders.

Identifiers

PMID42324338

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.