ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2026
Emerging directions in tauopathy research.
Abstract readReview
In one paragraph
Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
42 authors.
Luc BuéeLille Neuroscience and Cognition, Univ. Lille, Inserm, CHU-Lille, Lille, France.
Kristin R WildsmithEisai Inc., Nutley, New Jersey, USA.
Suvarna AlladiNational Institute of Mental Health and Neurosciences, Bengaluru, India.
Taylor BertucciNeural Stem Cell Institute, Albany, New York, USA.
Delphine BocheClinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Kathryn R BowlesUK Dementia Research Institute, University of Edinburgh, Edinburgh, Scotland, UK.
Adam BoxerEdward and Pearl Fein Memory and Aging Center, Weill Institute of Neuroscience, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
Jennifer BrummetCurePSP, New York, New York, USA.
Sarah L DeVosCurie.Bio, Boston, Massachusetts, USA.
Kristophe DiazCurePSP, New York, New York, USA.
Anna Jane DreyerDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Karen DuffUK Dementia Research Institute, University College London, London, UK.
Claudia Duran-AniotzLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.
Claire S DurrantUK Dementia Research Institute, University of Edinburgh, Edinburgh, Scotland, UK.
Kurt FarrellDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Igor C FontanaAlzheimer's Association, Chicago, Illinois, USA.
Nicolai FranzmeierInstitute for Stroke and Dementia Research (ISD), LMU University Hospital, Ludwig-Maximilians-Universität (LMU), Munich, Germany.
Bess FrostCenter for Alzheimer's Disease Research, Brown University, Providence, Rhode Island, USA.
Kanta HorieEisai Inc., Nutley, New Jersey, USA.
Petr KaňovskýDepartment of Neurology and Clinical Neuroscience Center, University Hospital Olomouc, Olomouc, Czech Republic.
Aimee W KaoEdward and Pearl Fein Memory and Aging Center, Weill Institute of Neuroscience, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
Simin MahinradAlzheimer's Association, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-5927-7130
Maura MalpettiDepartment of Clinical Neurosciences, University of Cambridge and Cambridge University Hospitals NHS Trust, University of Cambridge, Cambridge, UK.
Huw R MorrisMovement Disorders, UCL Queen Square Institute of Neurology, London, UK.
Carla PalleisDepartment of Neurology, LMU University Hospital, Ludwig-Maximilians-Universität (LMU), Munich, Germany.
Leonard PetrucelliDepartment of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
Jessica RexachDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Larisa ReydermanEisai Inc., Nutley, New Jersey, USA.
Amy RommelRainwater Charitable Foundation, Fort Worth, Texas, USA.
James B RoweDepartment of Clinical Neurosciences, MRC Cognition and Brain Sciences Unit and Cambridge University Hospitals NHS Trust, University of Cambridge, Cambridge, UK.
Sandra M Sanabria BohórquezImaging Data Insights, Research & Early Development, Genentech, Inc., South San Francisco, California, USA.
Chihiro SatoDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
Michael SchöllDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
Anja SchneiderGerman Center of Neurodegenerative Diseases, DZNE, Bonn, Germany.
Rohan de SilvaReta Lila Weston Institute and Department of Clinical & Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.
Heather M SnyderAlzheimer's Association, Chicago, Illinois, USA.
Lawren VandeVredeEdward and Pearl Fein Memory and Aging Center, Weill Institute of Neuroscience, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
Andrew W VargaDavid M. Rapoport Sleep Research Laboratory, Division of Pulmonary, Critical Care, and Sleep Medicine, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Jacob W VogelDepartment of Clinical Sciences, SciLifeLab, Lund University, Lund, Sweden.
Felix L YehTranslational Medicine, Genentech, A Member of the Roche Group, South San Francisco, California, USA.
Andrew S YooDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, USA.
Maria C CarrilloAlzheimer's Association, Chicago, Illinois, USA.
Funding
Investigating regional and cellular vulnerabilities to tau pathology in young-onset Alzheimer's diseaseR01AG075802 · NIA · MAYO CLINIC JACKSONVILLE · PI BERNARDINO Francesco GHETTI, Lea Tenenholz Grinberg · 2022 to 2026
$15.5MIdentification and Characterization of Cell-Specific Transposable Elements Implicated on Alzheimer Disease and Healthy AgingR01AG078964 · NIA · WASHINGTON UNIVERSITY · PI Carlos Cruchaga, Bess Frost · 2022 to 2026
$9.0MInvestigating the Functional Impact of AD Risk Genes on Neuro-Vascular InteractionsU01AG072464 · NIA · REGENERATIVE RESEARCH FOUNDATION · PI HARARI, OSCAR, KAMPMANN, MARTIN · 2021 to 2025
$8.7MEffects of Successful OSA TreatmENT on Memory and AD BIomarkers in Older AduLts (ESSENTIAL)R01AG080609 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI OSORIO, RICARDO S, STONE, KATIE L · 2023 to 2024
$7.4MAn automated machine learning approach to language changes in Alzheimer’s disease and frontotemporal dementia across Latino and English-speaking populationsR01AG075775 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, Adolfo Martin Garcia · 2023 to 2026
$7.2MUS-South American Initiative for Genetic-Neural-Behavioral Interactions in Human Neurodegenerative ResearchR01AG057234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Claudia Duran-Aniotz, Agustin M. Ibanez · 2019 to 2026
$6.1MDefining the molecular spectrum of white matter vascular lesionsRF1NS139972 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CARMICHAEL, STANLEY THOMAS, HINMAN, JASON D · 2024 to 2024
$4.7MImpact of sleep apnea and its treatment on memory and tau accumulation in the brainR01AG066870 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI OSORIO, RICARDO S, VARGA, ANDREW W · 2020 to 2024
$3.7MRole of slow waves and sleep apnea in memory and risk for Alzheimer diseaseR01AG056682 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI VARGA, ANDREW W · 2017 to 2021
$3.5MHippocampal iPSC-Derived Assembloids to Model Interneuron and Circuit Vulnerability in Genetically-Encoded Amnestic and Behavioral DementiaRF1NS144499 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REXACH, JESSICA E · 2025 to 2025
$3.1MCircadian Disturbance and Dementia in Latin AmericaR01AG083799 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Kun Hu, Agustin M. Ibanez · 2023 to 2026
$3.0MRole of central and peripheral immune crosstalk in FTD-Grn neurodegenerationRF1NS128800 · NINDS · UNIVERSITY OF FLORIDA · PI FINKBEINER, STEVEN M, TANSEY, MARIA DE LOURDES GAMEZ · 2022 to 2022
$2.4MAgentura Pro Zdravotnický Výzkum České RepublikyAlzheimerfondenAlzheimer's Association 2018-AARG-589632Alzheimer's Association AARGD-24-1310017;AARG-1027406Alzheimer's Association SG-20-725707Alzheimer's Research UK ARTEXT2010-1Alzheimer's Research UK ART/PG2006/4Alzheimer's Research UK ARUK-EG2015A-4Alzheimer's Research UK ARUK-PG2018A-012Alzheimer's Research UK ARUK-RADF2021A-010Alzheimer's Research UK RT/ESG2005CAlzheimer's Society AS-PG-21-006ANID/FONDECYT Regular 1210622ANID/FONDECYT Regular 1250091ANID/FOVI 240065ANID/Proyecto Exploracion 13240170AZV CR NW25-04-00194BrightFocus Foundation A2026019SCambridge Centre for Parkinson-PlusCBD SolutionsCluster of Excellence ImmunoSensation EXC2151-39087304Cure Alzheimer's FundCure Parkinson's TrustCurePSP 685-2023-06-PathwayCzech Republic for the Conceptual Development of a Research Organization FNOL 0098892Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) EXC2145SyNergyDeutsche Forschungsgemeinschaft (DFG, German Research Foundation) ID390857198Drake FoundationEisai, Inc.Eisai WashU Research Exchange ProgramEli Lilly and CompanyElse Kröner-Fresenius-StiftungEuropean Union / Horizon Europe 101236426European Union's Horizon Europe research and innovation program 101112145European Union's Horizon Europe research and innovation program 101132933Familjen Rönström's FoundationFogarty International Center (FIC)German Federal Ministry of Education and Research FZK01EK2102AGerman Federal Ministry of Education and Research FZK01GP2213AGerman Federal Ministry of Education and Research PREPAREGlobal Brain Health InstituteInnovation platforms, Sahlgrenska Science ParkJames Dyson FoundationJM Dahl FoundationKnut och Alice Wallenbergs StiftelseMedical Research Council UK G0501033Medical Research Council UK MC_UU_00030/14Medical Research Council UK MR/T033371/1Merck Investigator Studies ProgramMichael J Fox FoundationMinisterstvo Zdravotnictví Ceské RepublikyNational Institute for Health and Care ResearchNational Institute for Health and Care Research University College London Hospitals Biomedical Research CentreNational Institute for Health Research (NIHR) Cambridge Biomedical Research Centre NIHR 203312National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke (NINDS) RF1NS128800National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke (NINDS) RF1NS139972National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke (NINDS) RF1NS144499National Institutes of Health (NIH), National Institute on Aging (NIA) K01AG070326National Institutes of Health (NIH), National Institute on Aging (NIA) R01AG056682National Institutes of Health (NIH), National Institute on Aging (NIA) R01AG057234National Institutes of Health (NIH), National Institute on Aging (NIA) R01AG066870National Institutes of Health (NIH), National Institute on Aging (NIA) R01AG075775National Institutes of Health (NIH), National Institute on Aging (NIA) R01AG075802National Institutes of Health (NIH), National Institute on Aging (NIA) R01AG078964National Institutes of Health (NIH), National Institute on Aging (NIA) R01AG080609National Institutes of Health (NIH), National Institute on Aging (NIA) R01AG081394-01National Institutes of Health (NIH), National Institute on Aging (NIA) R01AG083799National Institutes of Health (NIH), National Institute on Aging (NIA) R01AG21051National Institutes of Health (NIH), National Institute on Aging (NIA) R21AG081961National Institutes of Health (NIH), National Institute on Aging (NIA) R21AG088736National Institutes of Health (NIH), National Institute on Aging (NIA) R21AG091113National Institutes of Health (NIH), National Institute on Aging (NIA) U01AG072464National Research Foundation of Korea RS-2023-00263612NIHR Applied Research Collaboration East of EnglandParkinson's UKPSPAPSP AssociationRainwater Charitable FoundationReta Lila Weston Trust for Medical ResearchSahlgrenska AcademySwedish Alzheimer Foundation AF-1011738Swedish governmentSwedish government and the County Councils ALFGBG-813971Swedish government and the County Councils ALFGBG-965326Tau Consortuim/Rainwater Charitable Trustthe Swedish Brain Foundation FO2021-0311the Swedish Brain Foundation FO2024-0372the Swedish Research Council 2017-02869the Swedish Research Council 2021-02678the Swedish Research Council 2021-06545the Swedish Research Council 2023-06188Thiemann StiftungUCBUK Dementia Research Institute UK DRI-4211Västra Götaland Region R&D VGFOUREG-995510VetenskapsrådetWallenberg Centre for Molecular and Translational Medicine KAW2014.0363Wallenberg Centre for Molecular and Translational Medicine KAW2023.0371Wellcome Leap CARE Program CARE-2025-0883490149Wellcome Trust 220258
Abstract
The Tau Global Conference 2025, hosted by the Alzheimer's Association, CurePSP, and the Rainwater Charitable Foundation, convened international experts from academia, industry, government, and philanthropy to explore advances and challenges in tauopathy research. The meeting highlighted progress across tau biology, including emerging models of tau regulation, degradation, and propagation; advances in biomarker development for the diagnosis and staging of tauopathies; and evolving therapeutic strategies targeting diverse aspects of tau pathophysiology. Discussions also emphasized the importance of cross-sector collaboration, and global initiatives to address disparities in tau research. This report synthesizes key insights from the conference and underscores the critical role of interdisciplinary, biomarker-driven, and globally inclusive approaches in accelerating the translation of tau research into effective clinical applications.
Indexed as
Biomedical ResearchTauopathiestau ProteinsAnimalsBiomarkersHumansBiomarkerstau Proteinsbiomarkersneurodegenerationprecision medicinetauopathiestherapeutics
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.