Evidence map›Paper›PMID 42324626›Full record

ArticleGut microbes2026

Indole-3-acetic acid production is rare among gut bacteria and reflects OFOR-driven amino acid oxidation in acetogens.

Mary E DeFeo, Yuanyuan Liu, Zhiwei Zhou, Steven K Higginbottom, Dylan Dodd

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Mary E DeFeoDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Yuanyuan LiuDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Zhiwei ZhouDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Steven K HigginbottomDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Dylan DoddDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.

Funding

Microbiota-based probiotics to treat inborn errors in metabolismR01AT011396 · NCCIH · STANFORD UNIVERSITY · PI Dylan Dodd · 2022 to 2026
$2.9M
Physiology of bacterial metabolism in the human gut microbiomeR35GM142873 · NIGMS · STANFORD UNIVERSITY · PI DODD, DYLAN · 2021 to 2025
$2.0M
Modulation of gut bacteria-derived host metabolitesK08DK110335 · NIDDK · STANFORD UNIVERSITY · PI DODD, DYLAN · 2018 to 2021
$573k
NCCIH NIH HHS R01 AT011396NIDDK NIH HHS K08 DK110335NIGMS NIH HHS R35 GM142873
6 · The paper itself

Abstract

Indole-3-acetic acid (IAA) is a tryptophan-derived gut microbial metabolite with reported anti-inflammatory activities, but the organisms and anaerobic pathways that support robust production remain unclear. Screening 206 human gut bacterial isolates by LC-MS revealed that IAA production is rare: only five strains exceeded the limit of quantitation, and high-capacity production was confined to the acetogens

Indexed as

Amino AcidsBacteriaGastrointestinal MicrobiomeIndoleacetic AcidsAnimalsGerm-Free LifeHumansMiceOxidation-ReductionAmino Acidsindoleacetic acidIndoleacetic Acidsacetogenesisamino acid oxidationanaerobic biochemistryBacterial metabolismgut microbiotaWood-Ljungdahl pathway

Identifiers

PMID42324626
PMCPMC13290082

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.