Identification of (-)-Epicatechin 3-gallate from seeds of Platycarya strobilacea with dual-functions of direct antivirus and plant immune elicitation against TMV.

Zilong Hu, Haiyan Zhang, Asif Zaman Khan, Xue Li, Jiachen Ma, Xiangrong Tian, Lili Huang

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Article in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Zilong HuCollege of Forestry, Northwest A&F University, Yangling, China.

Haiyan ZhangCollege of Forestry, Northwest A&F University, Yangling, China.

Asif Zaman KhanCollege of Forestry, Northwest A&F University, Yangling, China.

Xue LiCollege of Forestry, Northwest A&F University, Yangling, China.

Jiachen MaCollege of Forestry, Northwest A&F University, Yangling, China.

Xiangrong TianCollege of Forestry, Northwest A&F University, Yangling, China.ORCID https://orcid.org/0000-0001-9964-3038

Lili HuangState Key Laboratory of Crop Stress Biology for Arid Areas, Northwest A&F University, Yangling, China.ORCID https://orcid.org/0000-0002-7085-7646

Funding

The work was supported by the grants of the National Natural Science Foundation of China (32270423 and 31870331), and the Key Research and Development Project of Shaanxi Province of China (2025CY-JJQ-87). Authors are thanks for manager Wei Zhou from Shaanxi Xiangju Pharmaceutical Group Co. Ltd. of China to provide the seeds of P. strobilacea.

6 · The paper itself

Abstract

backgroundGlobal crop losses caused by plant viruses, particularly tobacco mosaic virus (TMV), amount to billions of dollars per year, necessitating the urgent development of potent and environmentally friendly antiviral agents.

resultsTwelve natural products were identified from P. strobilacea seeds. Among them, (-)-Epicatechin 3-gallate (1) showed higher anti-TMV activity than ningnanmycin at 125-500 μg mL

conclusionThese results suggest that (-)-Epicatechin 3-gallate (1) is a promising lead compound for further development as both a direct-acting antiviral agent and a plant immune elicitor against TMV. © 2026 Society of Chemical Industry.

Indexed as

Antiviral AgentsCatechinJuglandaceaeNicotianaPlant DiseasesPlant ImmunityTobacco Mosaic VirusMolecular Docking SimulationSeedsAntiviral AgentsCatechin(‐)‐Epicatechin 3‐gallate (1)Platycarya strobilaceasystemic acquired resistancetobacco mosaic virus

Identifiers

PMID42324686

DOI10.1002/ps.71052

PMCPMC13569160

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