Evidence map›Paper›PMID 42325093›Full record

ArticleJCI insight2026

Single-cell spatial profiling identifies a mucosal-like epithelial signature in Hidradenitis suppurativa tunnels.

Peter Dimitrion, Jesse Veenstra, Deangelo Ferguson, Ping Wang, Jeffrey Cruz, Tasneem F Mohammad, Ian Loveless, Aamir Siddiqui, Iltefat H Hamzavi, Li Zhou and 2 more

Abstract read
In one paragraph

Article in JCI insight, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Peter DimitrionCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, Michigan, USA.
Jesse VeenstraCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, Michigan, USA.
Deangelo FergusonDepartment of Plastic Surgery, Henry Ford Health, Detroit, Michigan, USA.
Ping WangCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, Michigan, USA.
Jeffrey CruzCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, Michigan, USA.
Tasneem F MohammadCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, Michigan, USA.
Ian LovelessCenter for Bioinformatics, Department of Public Health Sciences, Henry Ford Health, Detroit, Michigan, USA.
Aamir SiddiquiDepartment of Plastic Surgery, Henry Ford Health, Detroit, Michigan, USA.
Iltefat H HamzaviCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, Michigan, USA.
Li ZhouCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, Michigan, USA.
Indra AdriantoCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, Michigan, USA.
Qing-Sheng MiCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, Michigan, USA.

Funding

Using whole-exome sequencing to uncover key genetic variants related to Hidradenitis Suppurativa risk in African American and Hispanic population.R01AR078688 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIAO, WILSON, MI, QING-SHENG · 2021 to 2025
$4.1M
VPS72 controls Treg cell stability and adaptation to tumor microenvironmentR01CA284740 · NCI · HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES · PI FANG, DEYU, MI, QING-SHENG · 2023 to 2025
$3.1M
Whole genome sequencing analysis of hidradenitis suppurativaR01AR083553 · NIAMS · HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES · PI Indra Adrianto, QING-SHENG MI · 2024 to 2026
$2.2M
Genetic risk of hidradenitis suppurativa in African AmericansR21AR079089 · NIAMS · HENRY FORD HEALTH SYSTEM · PI ADRIANTO, INDRA, MI, QING-SHENG · 2022 to 2023
$520k
NCI NIH HHS R01 CA284740NIAMS NIH HHS R01 AR078688NIAMS NIH HHS R01 AR083553NIAMS NIH HHS R21 AR079089
6 · The paper itself

Abstract

Tunnels in HS have a transcriptional signature like mucosal epithelia that may contribute to inflammation in HS.

Indexed as

Hidradenitis SuppurativaMucous MembraneEpitheliumHumansSingle-Cell AnalysisBioinformaticsCellular immune responseDermatologyImmunology

Identifiers

PMID42325093
PMCPMC13313476

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.