Endogenous metabolite signaling orchestrates tumor immune evasion.

Xiaorui Liu, Congqing Jiang, Youjun Li

Abstract readReview

In one paragraph

Review in Cell insight, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xiaorui LiuDepartment of Colorectal and Anal Surgery, Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, 430072, Hubei, China.

Congqing JiangDepartment of Colorectal and Anal Surgery, Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, 430072, Hubei, China.

Youjun LiDepartment of Colorectal and Anal Surgery, Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, 430072, Hubei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endogenous metabolites are a class of bioactive metabolic molecules synthesized endogenously within the organism that mediate core physiological processes, spanning bioactive small-molecule compounds, carbohydrates, nucleotides, and gut microbial metabolites. Serving as the fundamental basis for sustaining normal physiological homeostasis, these metabolites also exert pivotal regulatory effects within the tumor microenvironment, especially during the progression of cancer immune evasion. This review encapsulates the major classifications, biological functions, and underlying mechanisms of endogenous metabolites, with a dedicated focus on dissecting the molecular pathways through which these metabolites either facilitate or suppress tumor immune evasion. Additionally, it delves into the interplay between endogenous metabolites and immune checkpoint blockade therapy, with the ultimate goal of offering innovative research insights and promising therapeutic targets for the advancement of cancer immunotherapy.

Indexed as

Endogenous metabolitesImmune checkpoint blockade therapyImmune evasionTumor metabolic reprogramming

Identifiers

PMID42325245

DOI10.1016/j.cellin.2026.100330

PMCPMC13277534

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.