Assessment of

Background: Periodontitis is a chronic inflammatory disease resulting from microbial biofilm and host immune responses, leading to progressive loss of periodontal attachment. Although scaling and root planing (SRP) remains the primary nonsurgical treatment, adjunctive therapies may enhance clinical and biochemical outcomes. This study evaluated the efficacy of a thermoreversible Material and methods: Thirty patients (90 sites) with Stage III periodontitis were randomly assigned to three groups: Group I - SRP alone, Group II - SRP + tetracycline fibers, and Group III - SRP + 5% MO gel. Clinical parameters and gingival crevicular fluid biomarkers (periostin, nitric oxide [NO], and total antioxidant capacity [TAOC]) were assessed at baseline and two months post-treatment. Data were analyzed using ANOVA followed by post-hoc comparisons. Results: All groups showed significant clinical improvement (p < 0.001). Adjunctive groups demonstrated greater reductions in plaque, gingival, and bleeding indices than SRP alone. The MO group showed a significantly higher increase in periostin levels compared with the tetracycline group (p = 0.029) and the largest reduction in NO concentrations (p < 0.001). TAOC increased across all groups, with numerically higher yet nonsignificant values in the MO group. Conclusion: The