ReviewInternational journal of nanomedicine2026
How PLGA Microspheres are Emerging as a Key Drug Delivery System.
Review in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- PEGylated PLGA Nanoformulations For Effective Immunomodulatory Actors In Non-Small Cell Lung Cancer.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Poly(lactic-co-glycolic acid) (PLGA) microspheres are a clinically established platform for sustained and controlled drug delivery, offering tunable degradation and reduced dosing frequency. This review critically appraises PLGA microsphere technology, linking materials science with clinical translation. We examine how molecular parameters-molecular weight, lactide-to-glycolide ratio, and terminal group chemistry-affect degradation and release kinetics. Key fabrication methods (emulsion-solvent evaporation, spray drying, membrane emulsification, and microfluidics) are compared for their control over encapsulation efficiency, particle size, and scalability. Release mechanisms, including diffusion, swelling, and erosion, are discussed alongside strategies to mitigate burst release. The review also addresses in vivo pharmacokinetics, recent clinical progress in oncology and vaccine delivery, regulatory challenges, manufacturing hurdles, and future directions such as stimuli-responsive microspheres and AI-guided formulation design.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.