ArticleLancet regional health. Americas2026
Person-centered choice and mHealth support for same-day delivery of long-acting injectable cabotegravir (ImPrEP CAB Brasil): a prospective, open-label, multicenter, quasi-experimental implementation study.
Article in Lancet regional health. Americas, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05515770 (An Implementation Study of Long-acting Injectable Cabotegravir), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Implementation Study of Long-acting Injectable Cabotegravir (CAB-LA) for HIV Pre-Exposure Prophylaxis (PrEP) Among Young MSM, Non-binary and Transgender Persons (The ImPrEP CAB Study)
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27 authors.
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Abstract
Background: Long-acting injectable cabotegravir (CAB-LA) offers a promising alternative to daily oral PrEP. However, studies evaluating PrEP choice and mHealth tools designed to support informed PrEP decision-making in real-world public health settings are scarce. We evaluated PrEP choice and the impact of an mHealth tool. Methods: ImPrEP CAB Brasil is a prospective, multicenter, quasi-experimental, implementation study conducted in six public health services in Brazil. Eligible participants were PrEP-naïve cisgender men, transgender and non-binary persons who have sex with men, aged 18-30 years, who tested negative for HIV. Participants were offered a person-centered model that provided a choice between same-day delivery of CAB-LA and oral PrEP. To support informed decision-making, participants were allocated (1:1) to standard-of-care counseling (SOC) or mHealth tool + SOC (first half enrolled in each site received SOC and the remaining received mHealth + SOC). Modified Poisson regression models estimated the effects of exposures of interest, study arm and Decisional Conflict Scale (DCS), on CAB-LA choice. Registered at ClinicalTrials.gov (NCT05515770). Findings: From October-2023 to October-2024, 1447 participants were enrolled: 738 (51.0%) to SOC arm and 709 (49.0%) to mHealth + SOC arm. Overall, 1201 (82.9%) participants chose CAB-LA. Participants allocated to mHealth + SOC arm were more likely to choose CAB-LA compared to SOC (PR: 1.15; 95% CI 1.10-1.21). Higher DCS scores were associated with a lower prevalence ratio of choosing CAB-LA (PR: 0.99; 95% CI 0.98-0.99). A total of 678 (95.7%) participants were satisfied with the mHealth tool and 659 (92.9%) found it supported PrEP decision. Interpretation: We found a strong preference for CAB-LA among young sexual and gender diverse populations. The mHealth intervention was highly acceptable and supported informed-decision, indicating its utility as a scalable strategy in real-world settings. These findings are crucial for guiding the equitable scale-up of CAB-LA and advancing HIV prevention in Latin America. Funding: Unitaid, WHO, Brazilian Ministry of Health.
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