ArticlePlastic and reconstructive surgery. Global open2026
Global Research Trends and Thematic Evolution in Injectable Aesthetic Medicine: A 25-year Bibliometric Analysis (2000-2025).
Article in Plastic and reconstructive surgery. Global open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Injectable aesthetic procedures, particularly botulinum toxin and hyaluronic acid fillers, have revolutionized minimally invasive facial rejuvenation. However, the global research landscape and thematic evolution of this field remain unclear. This study presents a bibliometric and thematic evolution analysis of injectable aesthetic medicine from 2000 to 2025. Methods: Bibliographic data were retrieved from the Dimensions database and analyzed using the bibliometrix R package. A total of 1153 English-language publications were evaluated for annual trends, journal distribution, keyword networks, and thematic transitions across 3 time periods (2000-2009, 2010-2016, and 2017-2025). Results: Global publication output showed exponential growth, particularly after 2017, reflecting increasing clinical and academic interest in minimally invasive rejuvenation. The most frequent keywords-hyaluronic acid, botulinum toxin, complications, ultrasound, and artificial intelligence (AI)-highlighted the transition from material-focused studies to imaging- and technology-assisted precision aesthetics. Six major research clusters were identified, covering safety, anatomy, materials and technology, patient outcomes, ultrasound guidance, and AI-assisted analysis. Conclusions: Over the past 25 years, injectable aesthetic research has evolved from empirical artistry toward evidence-based, technology-driven practice. Emerging trends emphasize vascular safety, ultrasound-guided injection, and AI-enhanced symmetry assessment. Future research should prioritize multicenter collaboration, standardized outcome reporting, and translational integration of clinical, material, and computational sciences to advance individualized, intelligent aesthetic medicine.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.