Evidence map›Paper›PMID 42325525›Full record

ArticleFrontiers in nutrition2026

Co-fermentation of

Jian Zhang, Shuo Zhang, Zhiyu Chen, Chencen Lai, Shiyu Zhang, Fangling Feng, Pengjiao Wang, Xuncai Huang, Min Zhang, Xiuli Gao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jian Zhang *State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine and School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, China.
Shuo Zhang *State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine and School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, China.
Zhiyu ChenState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine and School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, China.
Chencen LaiState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine and School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, China.
Shiyu ZhangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine and School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, China.
Fangling FengState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine and School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, China.
Pengjiao WangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine and School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, China.
Xuncai HuangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine and School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, China.
Min ZhangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine and School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, China.
Xiuli GaoState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine and School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Diarrhea-predominant irritable bowel syndrome (IBS-D) is a common functional bowel disorder closely associated with gut microbiota dysbiosis and gut-brain axis dysfunction. However, effective treatment options remain limited. In this study, we investigated the therapeutic effects and underlying mechanisms of an extract derived from the pulp of Methods: Results: Co-fermentation significantly increased the variety and content of bioactive components (e.g., flavonoids and polyphenols) in Conclusion: Our findings demonstrate that FRRTP alleviates IBS-D symptoms in mice by modulating the gut microbiota and correcting metabolic disturbances, supporting its potential development as a functional food or therapeutic agent for IBS-D.

Indexed as

co-fermentationgut- brain axisgut microbiotaIBS-DmetabolomicsRosa roxburghii Tratt

Identifiers

PMID42325525
PMCPMC13279404

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.