Evidence map›Paper›PMID 42325583›Full record

ArticleiScience2026

SNF1/AMPK controls its own localization by phosphorylating its activating kinase Sak1.

Hind Moukham, Marco Caligaris, Pauline Six, Francesco Padovani, Kurt M Schmoller, Claudio De Virgilio, Raffaele Nicastro, Farida Tripodi, Paola Coccetti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hind MoukhamDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milano, Italy.
Marco CaligarisDepartment of Biology, University of Fribourg, 1700 Fribourg, Switzerland.
Pauline SixDepartment of Biology, University of Fribourg, 1700 Fribourg, Switzerland.
Francesco PadovaniInstitute of Functional Epigenetics, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, Neuherberg, 85764 Munich, Germany.
Kurt M SchmollerInstitute of Functional Epigenetics, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, Neuherberg, 85764 Munich, Germany.
Claudio De VirgilioDepartment of Biology, University of Fribourg, 1700 Fribourg, Switzerland.
Raffaele NicastroDepartment of Biological Sciences, University of Limerick, V94 T9PX Limerick, Ireland.
Farida TripodiDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milano, Italy.
Paola CoccettiDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milano, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SNF1/AMPK is a key metabolic regulator in yeast, orchestrating cellular responses to glucose depletion. Its activation relies on phosphorylation of the α subunit by the upstream kinases Sak1, Tos3, and Elm1, with Sak1 as the primary regulator. Interestingly, ten Snf1-dependent phosphosites on Sak1 have been reported. Here, we explored Snf1 nuclear/cytoplasmic dynamics upon glucose depletion by using single-cell live imaging. Snf1 nuclear entry peaks rapidly after glucose depletion in a Sak1-dependent manner, before gradually decreasing over time. In the

Indexed as

Cell biologyMolecular biologySystems biology

Identifiers

PMID42325583
PMCPMC13276779

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.