Evidence map›Paper›PMID 42325638›Full record

ArticleACS bio & med chem Au2026

Side-by-Side Comparison of Different Thiol Bioconjugation Strategies for the Chemoselective Radiolabeling of Human Serum Albumin with Zirconium-89.

Julia Kronberger, Barbora Neuzilova, Anja Federa, Manuel Tieber, Amando Palombo, Marie R Brandt, Petra Heffeter, Christian R Kowol, Milos Petrik, Thomas L Mindt

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In one paragraph

Article in ACS bio & med chem Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Julia KronbergerInstitute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Währinger Straße 42, Vienna 1090, Austria.
Barbora NeuzilovaInstitute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University, Olomouc 779 00, Czech Republic.
Anja FederaInstitute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Währinger Straße 42, Vienna 1090, Austria.
Manuel TieberInstitute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Währinger Straße 42, Vienna 1090, Austria.
Amando PalomboInstitute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Währinger Straße 42, Vienna 1090, Austria.
Marie R BrandtInstitute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Währinger Straße 42, Vienna 1090, Austria.
Petra HeffeterCenter for Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, Vienna 1090, Austria.ORCID https://orcid.org/0000-0001-6401-8646
Christian R KowolInstitute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Währinger Straße 42, Vienna 1090, Austria.
Milos PetrikInstitute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University, Olomouc 779 00, Czech Republic.
Thomas L MindtInstitute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Währinger Straße 42, Vienna 1090, Austria.ORCID https://orcid.org/0000-0002-2090-1725

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Different bioconjugation strategies are available for the cysteine (Cys)-specific functionalization of proteins with different payloads, including imaging probes and (pro-)-drugs. Most commonly applied linkers include maleimides (mal); however, because of the sometimes-observed instability of the formed thiosuccinimidyl linkage, its suitability for in vivo applications has been challenged. Consequently, several alternatives have been developed and compared to mal as a benchmark, yet examples of a direct comparison among new methodologies are scarce. We herein report a comparison of the use of mal, phenyloxadiazole methyl sulfone (PODS), and vinylketone (VK) as functional groups for the thiol-specific functionalization of human serum albumin (HSA) via its available free Cys

Indexed as

DFO*human serum albuminPET imagingpositron emission tomographythiol bioconjugationZirconium-89

Identifiers

PMID42325638
PMCPMC13281002

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.