ArticleAmerican journal of translational research2026
Impact of hyperbaric oxygen therapy on serum lipid profiles and cognitive recovery in patients with post-stroke cognitive impairment: a retrospective cohort study.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPost-stroke cognitive impairment (PSCI) affects patients' quality of life, with hyperlipidemia being a key modifiable risk factor. Hyperbaric oxygen therapy (HBOT) may confer neuroprotection, but its effects on lipid metabolism and cognitive recovery in PSCI remain unclear.
objectiveTo evaluate the effects of HBOT combined with conventional therapy on lipid profiles and cognitive function in PSCI patients.
methodsThis retrospective cohort study included 115 PSCI patients divided into control (conventional treatment, n = 58) and HBOT (additional HBOT, n = 57) groups. Propensity score matching (PSM) balances baseline confounders were assessed. Outcomes included lipid parameters, cognitive scores [Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE)], and inflammatory markers.
resultsThe HBOT group showed significantly greater improvement in MoCA scores (4.00 ± 1.86 vs. 1.63 ± 1.79 points; mean difference 2.37, 95% CI 1.61-3.13,
conclusionHBOT combined with conventional rehabilitation significantly improves lipid metabolism and cognitive recovery in PSCI patients, potentially through lipid regulation and neurovascular protection.
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