SynthesisFrontiers in psychiatry2026
Epigenetics of bipolar disorder: a bibliometric landscape and visualization analysis.
Synthesis in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The incidence of bipolar disorder (BD) is an ongoing global public health concern, driving a heightened focus on elucidating its underlying pathophysiology. Mounting evidence indicates that epigenetic mechanisms play a pivotal role in the onset and progression of BD, presenting promising avenues for identifying novel biomarkers and therapeutic targets. However, a comprehensive bibliometric mapping of the intellectual structure and research frontiers in this rapidly evolving field is currently lacking. Methods: A systematic literature search was conducted to retrieve relevant publications spanning from January 1995 to October 2025, utilizing both the Web of Science Core Collection (WoSCC) and Scopus databases. Following rigorous screening and deduplication processes, bibliometric and visual analyses were executed using VOSviewer, CiteSpace, and the Bibliometrix R package. We systematically evaluated publication trends, collaboration networks (countries, institutions, and authors), and core themes. Results: A total of 1154 valid documents were included in the final analysis. The United States emerged as the most productive and influential country in this domain, with Harvard University identified as the leading institution. Kato T and Nöthen MM were recognized as the most prolific author and highly co-cited scientist, respectively. Molecular Psychiatry stood out as the core journal, featuring both the highest publication volume and citation frequency. Keyword co-occurrence and burst detection revealed that current research frontiers predominantly encompass histone modifications, HDAC inhibitors, long noncoding RNAs (lncRNAs), and the interplay between genetic variants (e.g., SNPs, CNVs) and epigenetic regulation. Conclusion: This bibliometric study delineates the developmental trajectory of epigenetic research in BD. The field is actively shifting from fundamental epigenetic mechanisms towards the exploration of dynamic regulatory networks (e.g., lncRNAs and HPA axis) and multi-omics integration. These findings provide researchers with a structural overview of current hotspots and highlight robust directions for future clinical translation and targeted epigenetic interventions.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.