ArticleInfection and drug resistance2026
Population Pharmacokinetics of Intravenous Colistin Sulfate in Critically Ill Patients with Pneumonia.
Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Objective: To characterize the population pharmacokinetics (PPK) of intravenous colistin sulfate in critically ill patients with pneumonia and explore dosing strategies using model-based simulations. Methods: Ten ICU patients receiving intravenous colistin sulfate for ≥72 h were enrolled. Serial plasma samples were collected after the fifth dose, and unbound concentrations were measured by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS). Population pharmacokinetic modeling and Monte Carlo simulations were performed. Results: A total of 130 plasma concentrations were analyzed. Non-compartmental analysis showed a mean C Conclusion: Colistin sulfate pharmacokinetics in critically ill patients were adequately described by a two-compartment model incorporating renal function. These exploratory findings support renal function-guided dosing and suggest a potential role for loading doses, but larger studies are needed to confirm dosing recommendations.
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