ArticleFrontiers in microbiology2026
Clinical characteristics and risk factor analysis of multidrug-resistant bacterial bloodstream infections in adult acute leukemia patients.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Bloodstream infection (BSI) is a common complication in adults with acute leukemia (AL), and the problem of multidrug-resistant (MDR) bacterial infection is exacerbated by inappropriate antibiotic use; therefore, identifying its clinical features and risk factors is critical to improving clinical outcomes. Methods: LASSO regression was employed for variable selection, followed by multivariate logistic regression to identify independent risk factors for multidrug-resistant bacterial bloodstream infection. Given the limited number of 30-day mortality events, LASSO regression combined with univariate logistic regression was used to preliminarily explore factors associated with 30-day mortality. Internal validation was performed using the bootstrap method with 1,000 resamples. Results: The median age of the patients was 56 years. The 30-day all-cause mortality rate was 10.5%. Gram-negative bacteria accounted for 71.053% of the infections, with Conclusion: This study provides important epidemiological data on blood infections in patients with AL in northeastern China, and provides a reference basis for optimizing infection prevention and control strategies based on local pathogens.
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