Evidence map›Paper›PMID 42326538›Full record

ArticleResearch square2026

Development of Human iPSC-based Microphysiogical Models of Transthyretin Amyloid Cardiomyopathy.

Marcus A C Williams, Junseong Park, Atharva R Mulay, Devin Mair, Colton R Lysaker, Vivek Jani, Desirae McKoy, Marcus Rhodehamel, Parisha Garg, Alex Wu and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Marcus A C WilliamsThe Johns Hopkins Medical Institutions.
Junseong ParkThe Johns Hopkins Medical Institutions.
Atharva R MulayThe Johns Hopkins Medical Institutions.
Devin MairThe Johns Hopkins Medical Institutions.
Colton R LysakerUniversity of Kansas Medical Center.
Vivek JaniThe Johns Hopkins Medical Institutions.
Desirae McKoyThe Johns Hopkins Medical Institutions.
Marcus RhodehamelThe Johns Hopkins Medical Institutions.
Parisha GargThe Johns Hopkins Medical Institutions.
Alex WuThe Johns Hopkins Medical Institutions.
Sangeeta KoiladaThe Johns Hopkins Medical Institutions.
Sharanya ParvathaneniThe Johns Hopkins Medical Institutions.
Brian LinThe Johns Hopkins Medical Institutions.
Heather M WilkinsUniversity of Kansas Medical Center.
Kavita SharmaThe Johns Hopkins Medical Institutions.
Joban VaishnavThe Johns Hopkins Medical Institutions.
Mark J RanekThe Johns Hopkins Medical Institutions.

Funding

Chip phosphorylation stimulates the degradation of mutant transthyretin to attenuate cardiac amyloidosisR01HL169273 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Mark John Ranek · 2024 to 2026
$2.1M
Chip phosphorylation stimulates the degradation of mutant transthyretin to attenuate cardiac amyloidosisR56HL169273 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI RANEK, MARK JOHN · 2023 to 2023
$670k
NHLBI NIH HHS R01 HL169273NHLBI NIH HHS R56 HL169273
6 · The paper itself

Abstract

Transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) is a restrictive cardiac disease caused by the deposition of TTR in the heart. TTR is synthesized by hepatocytes and circulates as a homotetramer carrying complex for thyroxine and retinol. Mutations in TTR destabilize the tetramer promoting its dissociation into monomers that can enter the heart and aggregate into amyloid fibrils driving cytotoxicity, fibrosis, impaired electrical conductivity, and progressive cardiac dysfunction. Mechanistic studies and therapeutic development have been limited by the lack of physiologically relevant human preclinical models. Here we describe the creation of two

Indexed as

amyloidosiscardiacin vitroiPSCsTransthyretin

Identifiers

PMID42326538
PMCPMC13278329

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.