ArticleCancer management and research2026
Berberine from Tibetan Medicine
Article in Cancer management and research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to identify berberine as the candidate active constituent of Methods: The antitumor activity of Results: BBR, a putatively annotated candidate metabolite putatively annotated from DME, attenuated ferroptosis in tumor-infiltrating CD8⁺ T cells, as confirmed by rescue assays using ferroptosis inducers. Accordingly, BBR treatment increased the proportion of functional CD8⁺ T cells while reducing exhausted T-cell populations in both in vitro and in vivo models. Mechanistically, BBR activated the NRF2-SLC7A11-GPX4 axis, leading to GPX4 upregulation and ferroptosis suppression in CD8⁺ T cells. Conclusion: Berberine, a candidate metabolite derived from
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.