ReviewArchives of rehabilitation research and clinical translation2026
Comparative Clinical Effectiveness of Intra-Articular Leukocyte-Rich Platelet-Rich Plasma and Hyaluronic Acid in Treating Knee Osteoarthritis Pain: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Review in Archives of rehabilitation research and clinical translation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To investigate the clinical effectiveness of intra-articular leukocyte-rich-platelet-rich plasma (LR-PRP) injections versus hyaluronic acid (HA) for pain management in patients with knee osteoarthritis (OA). Data Sources: Four electronic databsases were searched, including PubMed, EMBASE, Scopus, and Web of Science. Studies included in our analysis were published between November 1, 2011, and July 14, 2023. Study Selection: Randomized controlled trials (RCTs) that compared intra-articular LR-PRP versus HA injections in human adults diagnosed with knee OA. Data Extraction: The Cochrane Risk of Bias Tool was used to assess the risk of bias and methodological quality of included RCTs. The mean differences (MDs) and SDs with 95% CIs were used to compare continuous outcomes, using the Review Manager 5.4 software. Two reviewers independently extracted data on patient demographics and study outcome, including Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores, Visual Analog Scale scores, and adverse events. Data Synthesis: Nineteen RCTs involving 1771 patients were included. LR-PRP demonstrated significant pain relief compared with HA at 3 months posttreatment, but not at 1, 6, or 12 months. At 12 months, LR-PRP was associated with improved WOMAC physical function (MD=-6.37; 95% CI, -12.51 to -0.24; Conclusions: LR-PRP provides long-term functional improvements in patients with chronic knee OA, though evidence for short-term functional benefits remains limited. LR-PRP shows no long-term advantage over intra-articular HA injections in pain relief. Overall, the evidence does not support the superiority of LR-PRP over HA in managing knee OA.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.