ReviewFrontiers in pain research (Lausanne, Switzerland)2026
Targeting endoplasmic reticulum stress: a novel therapeutic strategy for neuropathic pain.
Review in Frontiers in pain research (Lausanne, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Silver Needle Thermotherapy Regulates TRPV1 to Alleviate Endoplasmic Reticulum Stress and Relieve Myofascial Pain.Journal of pain research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuropathic pain (NP) is a chronic and debilitating condition arising from lesions or diseases of the somatosensory system. Increasing evidence identifies endoplasmic reticulum (ER) stress as a central mechanism contributing to NP pathogenesis. Activation of the unfolded protein response disrupts cellular homeostasis and promotes many pathological processes, including neuroinflammation, oxidative stress, apoptosis, and ferroptosis. Notably, ER stress signaling exhibits strong cell-type specificity, affecting neurons, glial cells, and immune cells across both peripheral and central nervous systems. Targeting ER stress has therefore emerged as a promising therapeutic strategy. However, ER stress signaling remains complex, and clinical translation is still limited. This review summarizes current mechanisms and highlights emerging ER stress-targeted therapies for NP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.