Evidence map›Paper›PMID 42327608›Full record

ReviewInternational journal of microbiology2026

Antiviral Properties of Green-Synthesized Silver and Zinc Oxide Nanoparticles Against Coronaviruses: A Review.

Mohamed E A Mostafa, Ahmed E Ahmed, Mustafa N Abdulqader, Safaa A M Abdel-Karim, Atef S Elgebaly, Soheir A A Hagras

Abstract readReview
In one paragraph

Review in International journal of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohamed E A MostafaDepartment of Anatomy, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia, ut.edu.sa.ORCID https://orcid.org/0009-0001-2473-8312
Ahmed E AhmedDepartment of Medical Instruments Engineering, Medical Technical College, Al-Farahidi University, Baghdad, Iraq, uoalfarahidi.edu.iq.
Mustafa N AbdulqaderDepartment of Medicine, College of Medicine, Ninevah University, Ninevah, Iraq, uoninevah.edu.iq.ORCID https://orcid.org/0000-0003-3661-5915
Safaa A M Abdel-KarimDepartment of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt, zu.edu.eg.ORCID https://orcid.org/0000-0002-4603-4404
Atef S ElgebalyCollege of Medical Laboratory Techniques, Al-Farahidi University, Baghdad, Iraq, uoalfarahidi.edu.iq.ORCID https://orcid.org/0009-0003-4915-086X
Soheir A A HagrasPharmacy Department, Alnahda College, Al Munsiyah, Riyadh, Saudi Arabia.ORCID https://orcid.org/0000-0002-5461-5719

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is acknowledged that COVID-19 pandemic triggered by SARS-CoV-2 outbreak demands the development of efficient antiviral modalities independent of traditional vaccines and antiviral reagents. Metallic nanoparticles, such as silver nanoparticles (Ag-NPs) and zinc oxide nanoparticles (ZnO-NPs), have attracted considerable attention as promising antiviral agents due to their distinctive physicochemical properties and universal antimicrobial activity. This article examines the progress made between (2021 and 2025) in the green synthesis and the antiviral applications of Ag-NPs and ZnO-NPs against Coronavirus. The environmental friendly synthesis protocols using natural plant juices have been highlighted in this article due to their lower toxicity and greater biocompatibility. Various characterization methods, such as scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and UV-Vis spectrophotometry, have been used to examine nanoparticle morphology, stability, and surface characteristics. The findings reveald that Ag-NPs can suppress the viral replication by interacting strongly with S proteins, thereby hindering the cellular entry of the targeted Coronavirus. In contrast, ZnO-NPs showed that they have dual purposes: direct antiviral effects and immunomodulatory effects that involve cytokine regulation. The antiviral properties and the limitations of the individual nanoparticles are significantly modified by hybrid nanocomposites. In closing, the significance of using green-synthesized Ag-NPs and ZnO-NPs as antiviral materials is tremendous and warrants further exploration for antiviral applications. Nonetheless, there are still some unaddressed areas concerning the standardization of synthesis techniques and the validation of prolonged safety. Finally, it has been proven that there is a need for collaboration between nanotechnology and green technology in the development of environmentally benign, and universal antiviral medications against any future coronavirus pandemics.

Indexed as

antiviral activitycoronavirusesgreen synthesissilver nanoparticleszinc oxide nanoparticles

Identifiers

PMID42327608
PMCPMC13276291

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.