Chronic spontaneous cholinergic urticaria: advances in immunological mechanisms focusing on neuro-immune crosstalk and novel targeted therapeutic strategies.

Meilv Yang, Suxian Lin, Yang Lu, Huanzhi Jin, Xueliang Zhang, Zheyan Chen

Abstract readReview

In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Meilv Yang *Rheumatology and Immunology Department, Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou People's Hospital, Wenzhou, China.

Suxian Lin *Rheumatology and Immunology Department, Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou People's Hospital, Wenzhou, China.

Yang LuRheumatology and Immunology Department, Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou People's Hospital, Wenzhou, China.

Huanzhi JinDepartment of General Practice, Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou People's Hospital, Wenzhou, China.

Xueliang ZhangDepartment of General Practice, Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou People's Hospital, Wenzhou, China.

Zheyan ChenDepartment of Plastic and Reconstructive Surgery, Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou People's Hospital, The Wenzhou People's Hospital Affiliated of Hangzhou Medical College, Wenzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic spontaneous cholinergic urticaria (CSU-Chol) is a chronic inflammatory skin disorder characterized by intense pruritus and small wheals triggered by a rise in core body temperature. This review aims to systematically elucidate its complex pathogenesis, with a particular focus on the pivotal role of neuro-immune crosstalk in disease initiation and progression. We will provide an in-depth analysis of key immunological components, including aberrant mast cell activation, autoimmune responses, and dysregulation of the cytokine network. Furthermore, the review will detail how neuropeptides released from sensory nerve endings engage in dialogue with the immune system. Building on this mechanistic foundation, the article will further delineate the evolution of treatment strategies, from traditional antihistamines to emerging targeted therapies aimed at pathways involving IgE, IL-4/IL-13, and mast cell signaling. The overarching goal is to consolidate current knowledge to provide a theoretical basis for precise clinical diagnosis and management, while highlighting promising future research directions for this challenging condition.

Indexed as

Chronic UrticariaNeuroimmunomodulationAnimalsCytokinesHumansMast CellsMolecular Targeted TherapySignal TransductionCytokinesautoimmunitychronic spontaneous cholinergic urticariacytokinesmast cellsneuro-immune crosstalktargeted therapy

Identifiers

PMID42327770

DOI10.3389/fimmu.2026.1848638

PMCPMC13281078

What Socratic holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.