ReviewFrontiers in immunology2026
Toll-like receptors: versatile players in tumor.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Beyond receptor activation: biased toll-like receptor signaling in periodontal inflammation and regeneration.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Toll-like receptors (TLRs) are a class of pattern-recognition receptors first identified for their role in detecting microbial pathogens and initiating innate immune responses. Beyond pathogen defense, TLRs serve as crucial mediators connecting innate and adaptive immunity and contribute to processes such as tissue repair and remodeling. Owing to their functional versatility, TLRs are involved in multiple stages of tumor progression, presenting both anti- and pro-tumor effect. Here we review the functions of TLRs in physiologic activities, as well as their roles in tumor biology including tumorigenesis, tumor progression, tumor microenvironment, treatment sensitivity, tumor recurrence and patient prognosis. TLRs function as a context-dependent interface where host homeostasis and tumor subversion compete; the additive, synergistic, or antagonistic integration of their signals ultimately determines whether the balance tips toward tumor suppression or progression.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.