Evidence map›Paper›PMID 42327795›Full record

ArticleFrontiers in immunology2026

NPC1 promotes HTNV replication by controlling innate immune response.

Hansong Qi, Yuechun Wu, Rong Wei, Shengyao Chen, Jumin Zhou, Wei Hou, Xinglou Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hansong Qi *Key Laboratory of Genetic Evolution and Animal Models, Yunnan International Joint Laboratory of Zoonotic Viruses, Yunnan Key Laboratory of Biodiversity Information, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
Yuechun Wu *Key Laboratory of Genetic Evolution and Animal Models, Yunnan International Joint Laboratory of Zoonotic Viruses, Yunnan Key Laboratory of Biodiversity Information, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
Rong WeiKey Laboratory of Genetic Evolution and Animal Models, Yunnan International Joint Laboratory of Zoonotic Viruses, Yunnan Key Laboratory of Biodiversity Information, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
Shengyao ChenKey Laboratory of Genetic Evolution and Animal Models, Yunnan International Joint Laboratory of Zoonotic Viruses, Yunnan Key Laboratory of Biodiversity Information, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
Jumin ZhouKey Laboratory of Genetic Evolution and Animal Models, Yunnan International Joint Laboratory of Zoonotic Viruses, Yunnan Key Laboratory of Biodiversity Information, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
Wei HouState Key Laboratory of Virology, Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Xinglou YangKey Laboratory of Genetic Evolution and Animal Models, Yunnan International Joint Laboratory of Zoonotic Viruses, Yunnan Key Laboratory of Biodiversity Information, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hantaan virus (HTNV) causes the majority of hemorrhagic fever with renal syndrome (HFRS) across Asia, which imposes a substantial public health burden. Virus-host interaction, particularly protein-protein interactions, essentially determined the clinic outcomes of HFRS patients; however, the interactions between HTNV and host proteins remain largely uncharacterized. To identify host factors interacting with the HTNV glycoprotein (GP), we combined deep-learning-based virtual screening via MaSIF with immunoprecipitation coupled to mass spectrometry (IP-MS) and found that host cholesterol transporter protein Niemann-Pick C1 (NPC1) binds to HTNV GP and promotes HTNV replication. Specifically, NPC1 mitigates anti-viral innate immune response following HTNV infection, a function not previously documented among its known roles in viral infection. Our findings not only expand current understandings of NPC1 involving viral infection but also highlight its potential as an anti-viral target.

Indexed as

Hantaan virusHemorrhagic Fever with Renal SyndromeImmunity, InnateIntracellular Signaling Peptides and ProteinsNiemann-Pick C1 ProteinVirus ReplicationAnimalsHost-Pathogen InteractionsHumansProtein BindingIntracellular Signaling Peptides and ProteinsNiemann-Pick C1 ProteinNPC1 protein, humanglycoproteinHTNVinnate immunityNPC1protein interaction

Identifiers

PMID42327795
PMCPMC13279697

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.