ArticleFrontiers in neurology
State-dependent facial pulsation asymmetry and phase asynchrony measured by imaging photoplethysmography and their coupling with contingent negative variation in migraine.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To characterize imaging photoplethysmography (iPPG)-derived facial hemodynamic alterations across migraine states and examine their association with contingent negative variation (CNV), an electroencephalography-derived marker of anticipatory cortical activity. Methods: We enrolled 78 patients with migraine, including 60 assessed during the interictal phase (IP) and 18 assessed during the migraine attack phase (MAP), together with 72 healthy controls (HC). Short facial videos were analyzed across three facial angiosomes: the lateral forehead, mid-forehead, and cheek. Two peripheral pulsation metrics were derived: bilateral pulsation amplitude asymmetry (BPA) and bilateral pulsation phase difference (BPP). CNV recordings obtained during an S1-S2 paradigm were used to quantify initial CNV (iCNV), overall CNV (oCNV), and terminal CNV (tCNV) amplitudes and areas. Group effects and CNV-iPPG associations were evaluated using linear mixed-effects models adjusted for age and sex. Sensitivity analyses evaluated potential confounding by mood symptoms, headache impact, acute medication use, and unequal IP-MAP sample sizes. Exploratory receiver operating characteristic analyses were used to assess within-cohort separability before and after adjustment for age and sex. Results: BPA and BPP were higher in patients with migraine than in HC across facial angiosomes. CNV metrics showed state-dependent differences: IP participants had higher iCNV, oCNV, and tCNV amplitudes and areas than both HC and MAP participants, whereas MAP participants were generally comparable to HC. CNV amplitudes were positively associated with BPA and BPP, with angiosome-dependent slopes and stronger group differences in iCNV-related models. Exploratory analyses showed high within-cohort separability for mid-forehead iPPG metrics in distinguishing migraine from HC and for central CNV metrics in distinguishing MAP from IP. Conclusion: Migraine is associated with increased facial pulsation asymmetry and phase asynchrony, state-dependent CNV alterations, and angiosome- and state-dependent central-peripheral coupling. These candidate markers require validation in larger, longitudinal, and external cohorts.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.