ArticleFrontiers in pediatrics2026
Integrated meta-analysis, network pharmacology and experimental validation to explore the mechanism of traditional Chinese medicine against neonatal pneumonia: focus on naringenin/MAPK1.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and purpose: This study aimed to systematically analyze the clinical efficacy of traditional Chinese medicine (TCM) in treating neonatal pneumonia (NP), identify core active components and investigate the underlying molecular mechanisms, thereby providing reliable support for the clinical application of TCM in NP. Methods: A meta-analysis of seven clinical studies was conducted to identify effective TCM formulas. Network pharmacology approaches were applied to screen active ingredients, predict common targets, construct protein-protein interaction networks, and perform functional enrichment and molecular docking analyses. Results: A meta-analysis confirmed significant clinical efficacy of the TCM bath composed of Conclusion: Naringenin exerts therapeutic effects on NP partly by targeting MAPK1 and regulating inflammatory signaling pathways. Our systematic study provides novel theoretical and experimental evidence for the clinical application of TCM in NP.
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