ArticleJournal of education and health promotion2026
Comparing additive effect of dexmedetomidine and neostigmine to bupivacaine on postspinal anesthesia cesarean section induced pain intensity: A health promotion Approach.
Article in Journal of education and health promotion, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThis study pursued the goal to evaluate the effect of dexmedetomidine and neostigmine on pain, sedation, and locomotor properties during and after surgery in the patients receiving intrathecal bupivacaine for spinal anesthesia in women with elective cesarean section (CS) and to assess the effective dose of dexmedetomidine and neostigmine. MATERIALS AND
methodsThe present clinical trial study was performed on the women as the candidates for elective CS between 2022 and 2023 in Imam Khomeini Educational and Medical Center located in Mazandaran province. The patients for spinal anesthesia were divided into two groups: (1) receiving bupivacaine and dexmedetomidine (1 μg) and (2) receiving bupivacaine and neostigmine (10 μg). Bromage, Visual Analog Scale, and Ramsay scores were recorded in each patient at the intervention time, 2, 4, 8, and 12 h after the onset of anesthesia, along with the demographic and clinical baseline characteristics. The generalized statistical estimating model (GEE) was used to compare the variance of the aforementioned criteria between the two groups. The statistical significance level of 0.05 was used, and all statistical analyses were conducted using STATA/MP. 17: Stata|; M Statistical Software: Release 17. College Station, TX: StataCorp LLC.
resultsOne hundred ten individuals participated in this study. The study participants' mean age was 31.56 ± 5.92. The level of pain intensity in group 1 was lower than that of group 2, which was statistically significant (
conclusionUsing dexmedetomidine exerts a greater and better effect on reducing pain intensity and boosts the sedative effect of neostigmine in the patients undergoing CS. It is suggested to run a study with a larger statistical community to deal with this issue. The results of this study can be useful in making prevention decisions and maintaining performance of women.
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