Evidence map›Paper›PMID 42328445›Full record

ReviewInternational journal of biological sciences2026

Reimagining AHR in Cancer: From Environmental Sensor to Novel Immunomodulatory Therapeutic Target.

Yuanhao Peng, Yaxin Zhao, Yangying Zhou, Shuang Liu, Desheng Xiao, Yongguang Tao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yuanhao PengHunan Key Laboratory of Cancer Metabolism, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Hunan Key Laboratory of Cancer Metabolism Changsha, 410013, Hunan, China.
Yaxin ZhaoDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China.
Yangying ZhouDepartment of Oncology, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China.
Shuang LiuDepartment of Oncology, Institute of Medical Sciences, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China.
Desheng XiaoDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China.
Yongguang TaoHunan Key Laboratory of Cancer Metabolism, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Hunan Key Laboratory of Cancer Metabolism Changsha, 410013, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aryl hydrocarbon receptor (AHR) is an environmental sensor in mammals and a ligand-dependent, highly conserved transcription factor. It belongs to the basic helix-loop-helix family of transcription factors and is the only known ligand-activated member within this family. Previous studies have revealed its significant roles in physiological regulation, metabolic homeostasis, and tumorigenesis.

Indexed as

NeoplasmsReceptors, Aryl HydrocarbonAnimalsEpigenesis, GeneticHumansMitochondriaTumor MicroenvironmentReceptors, Aryl HydrocarbonAHRcancercell fateepigeneticsmitochondrial metabolismtumor immunity

Identifiers

PMID42328445
PMCPMC13282741

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.