ArticleInternational journal of biological sciences2026
Dual inhibition of PRMT1 and SUV39H1 suppresses breast cancer progression and enhances immunotherapy response.
Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein arginine methyltransferase 1 (PRMT1) dysregulation is frequently observed in various human cancers, including breast cancer. However, the antitumor efficacy of PRMT1 inhibitors remains limited in the treatment of breast cancer. Here, we propose a dual epigenetic inhibition strategy that effectively suppresses breast cancer growth and metastasis. We demonstrate that GSK3368715, a small-molecule inhibitor of PRMT1, downregulates the protein levels of the histone lysine methyltransferase SUV39H1 by enhancing its ubiquitination. Dual inhibition of PRMT1 and SUV39H1 results in significantly greater suppression of tumor growth and metastasis compared to either monotherapy, supporting the synergistic effects of targeting two epigenetic regulators. Consistently, dual inhibition markedly suppresses the growth of breast cancer organoids relative to single-agent treatments. Mechanistically, co-inhibition of SUV39H1 and PRMT1 enhances chromatin accessibility in promoter regions, thereby promoting the expression of key regulators involved in cell growth and migration. Furthermore, dual inhibition increases infiltration of CD8
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.