ArticleFrontiers in medicine2026
Association between leptin gene polymorphisms and hematological metabolic parameters in obese Saudi adults.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Obesity represents a major global public health challenge. However, among the Middle Eastern countries and members of the Gulf Cooperation Council, the Kingdom of Saudi Arabia (K.S.A) has been particularly affected, with prevalence rates exceeding 24.7%. The impact of obesity on hematological parameters has been previously established; nevertheless, the relationship between genetic variants and obesity-related hematological changes in the Saudi population remains unexplored. Aim: This study aimed to investigate the hematological and metabolic profiles of obese and non-obese Saudi subjects while determining potential associations between Methods: In the current study, we examined 202 Saudi adults (102 obese, 100 non-obese). Comprehensive hematological profiling was performed alongside genetic analysis of the leptin gene ( Results: Obese subjects demonstrated significant alterations in hematological parameters compared to controls, including elevated white blood cell, platelet counts and decreased red blood cell counts. Red blood cell indices were significantly reduced in the obese group, including hemoglobin, hematocrit and mean corpuscular volume. These changes showed progressive alterations across obesity classes. Genetic analysis identified two Conclusion: This study reveals significant obesity-associated hematological alterations in the Saudi population, with progressive changes across obesity classes. The identification of
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