Evidence map›Paper›PMID 42328864›Full record

ArticlemBio2026

Maternal vaccination protects dams and prevents

Austin T Hertel, Cynthia M McMillen, Ryan M Hoehl, Zachary D Frey, Anita K McElroy, Amy L Hartman

Abstract read
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Austin T HertelCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-4355-855X
Cynthia M McMillenCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-9211-7908
Ryan M HoehlCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Zachary D FreyCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Anita K McElroyCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-6764-7536
Amy L HartmanCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-0857-2973

Funding

Practices CoreUC7AI180311 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI William Paul Duprex · 2023 to 2026
$13.2M
Immunology of Infectious DiseaseT32AI060525 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JoAnne L. Flynn · 2005 to 2026
$5.3M
Live-attenuated Rift Valley fever vaccines: comparative mechanisms of trans-placental transmission and vaccine efficacy for developing fetusesR01AI150792 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARTMAN, AMY L · 2020 to 2025
$3.7M
Host and Viral Determinants of Orthobunyavirus Vertical Transmission: Novel Model Systems to Understand the Mechanisms of Congenital Disease in Humans and RuminantsK01AI165965 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Cynthia Marie McMillen · 2023 to 2026
$499k
National Institute of Allergy and Infectious Diseases K01 AI165965National Institute of Allergy and Infectious Diseases R01 AI150792National Institute of Allergy and Infectious Diseases T32 AI060525National Institute of Allergy and Infectious Diseases UC7 AI180311NIAID NIH HHS K01 AI165965NIAID NIH HHS R01 AI150792NIAID NIH HHS T32 AI060525NIAID NIH HHS UC7 AI180311
6 · The paper itself

Abstract

IMPORTANCE: Rift Valley fever virus (RVFV) poses a formidable threat to pregnant animals and potentially to pregnant individuals and their developing fetuses. Despite this risk, pregnant individuals are rarely included in vaccine trials, leaving this potentially vulnerable population unprotected. Using a live-attenuated RVFV vaccine, we demonstrate that maternal vaccination is safe and protects both pregnant rats and their fetuses from congenital Rift Valley fever. Because live-attenuated vaccines are often contraindicated during pregnancy due to theoretical safety concerns, we further show that vaccination prior to pregnancy provides equivalent protection throughout future pregnancy. Taken together, these findings provide a blueprint for the preclinical evaluation of RVFV vaccines during pregnancy.

Indexed as

Infectious Disease Transmission, VerticalRift Valley FeverRift Valley fever virusVaccinationViral VaccinesAnimalsAntibodies, ViralDisease Models, AnimalFemalePlacentaPregnancyRatsVaccines, AttenuatedAntibodies, ViralVaccines, AttenuatedViral VaccinesbunyaviruspregnancyRift Valley feverRNA virusvaccinevertical transmission

Identifiers

PMID42328864
PMCPMC13464346

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.