Evidence map›Paper›PMID 42329147›Full record

ArticleEnvironmental science & technology2026

Exposure to Per- and Polyfluoroalkyl Substances (PFAS) Causes Dental Developmental Anomalies: Underrecognized Risk of Fluoride Bioaccumulation.

Motoki Okamoto, Shohei Yamashita, Nanako Kuriki, Susanne Brueckner, Ria Achong-Bowe, Melanie Mendonca, Juliana Sanches Trevizol, Natsumi Fujiwara, Shin Nakamura, Satoru Shindo and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental science & technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Motoki OkamotoDepartment of Oral Science and Translational Research, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, Florida 33314, United States.
Shohei YamashitaDepartment of Oral Science and Translational Research, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, Florida 33314, United States.
Nanako KurikiDepartment of Oral Science and Translational Research, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, Florida 33314, United States.
Susanne BruecknerDepartment of Oral Science and Translational Research, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, Florida 33314, United States.
Ria Achong-BoweDepartment of Oral Science and Translational Research, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, Florida 33314, United States.
Melanie MendoncaDepartment of Oral Science and Translational Research, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, Florida 33314, United States.
Juliana Sanches TrevizolDepartment of Oral Science and Translational Research, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, Florida 33314, United States.
Natsumi FujiwaraDepartment of Oral Health Care Management, Graduate School of Biomedical Sciences, Tokushima University, Kuramoto, Tokushima 770-8504, Japan.
Shin NakamuraDepartment of Oral Science and Translational Research, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, Florida 33314, United States.
Satoru ShindoDepartment of Oral Science and Translational Research, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, Florida 33314, United States.
Takumi MemidaDepartment of Oral Science and Translational Research, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, Florida 33314, United States.
Manabu MizuhiraBruker Japan K. K. Nano Analytics Division, 3-9 Moriyacho, Yokohama, Kanagawa 221-0022, Japan.
Navi Gill DhillonBiology I Halmos College of Arts and Sciences, Behavioral Neuroscience I College of Psychology, Nova Southeastern University, Fort Lauderdale, Florida 33314, United States.
Xiaozhe HanDepartment of Oral Science and Translational Research, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, Florida 33314, United States.
Toshihisa KawaiDepartment of Oral Science and Translational Research, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, Florida 33314, United States.
Marília Afonso Rabelo BuzalafDepartment of Biological Sciences, Bauru School of Dentistry, University of Sao Paulo, Bauru, 17012-902, Brazil.ORCID 0000-0002-5985-3951
Eric T EverettDepartment of Biomedical Sciences, Adams School of Dentistry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Maiko SuzukiDepartment of Oral Science and Translational Research, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, Florida 33314, United States.ORCID 0000-0002-1732-0663

Funding

Regulatory B Cells in the Amelioration of Immune-Mediated Periodontal DiseaseR01DE025255 · NIDCR · NOVA SOUTHEASTERN UNIVERSITY · PI HAN, XIAOZHE · 2015 to 2025
$5.8M
Role of OC-STAMP expressed on human osteoclasts in periodontitisR01DE029709 · NIDCR · NOVA SOUTHEASTERN UNIVERSITY · PI KAWAI, TOSHIHISA · 2020 to 2025
$2.8M
Epigenetic and Non-epigenetic Role of SIRT1 in Fluoride-induced Cell Stress Administrative Supplement.R01DE027648 · NIDCR · OHIO STATE UNIVERSITY · PI SUZUKI, MAIKO · 2018 to 2024
$2.2M
U-RISE at Nova Southeastern UniversityT34GM145509 · NIGMS · NOVA SOUTHEASTERN UNIVERSITY · PI GANNETT, PETER M. · 2023 to 2024
$499k
Impact of Diabetes hyperglycemia on peri-implantitisR21DE032156 · NIDCR · NOVA SOUTHEASTERN UNIVERSITY · PI HAN, XIAOZHE · 2023 to 2023
$435k
Health Effects of the Fluorinated Pollutants; PFAS on Enamel DevelopmentK02DE029531 · NIDCR · NOVA SOUTHEASTERN UNIVERSITY · PI SUZUKI, MAIKO · 2022 to 2024
$428k
Humanized mouse model of periodontitisR21DE034154 · NIDCR · NOVA SOUTHEASTERN UNIVERSITY · PI KAWAI, TOSHIHISA · 2024 to 2024
$424k
NIDCR NIH HHS K02 DE029531NIDCR NIH HHS R01 DE025255NIDCR NIH HHS R01 DE027648NIDCR NIH HHS R01 DE029709NIDCR NIH HHS R21 DE032156NIDCR NIH HHS R21 DE034154NIGMS NIH HHS T34 GM145509
6 · The paper itself

Abstract

Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals that persist in the environment and have potential health risks. Among them, 8:2 fluorotelomer alcohol (FTOH) undergoes microbial biotransformation in the environment into perfluorooctanoic acid (PFOA) and releases fluoride. While PFOA's toxic effects have been well-studied, the impact of PFOA (and its precursor 8:2 FTOH) on dental health is largely unknown. Moreover, it is not established whether, and to what extent, defluorination and fluoride bioaccumulation occur during the

Indexed as

FluoridesFluorocarbonsAnimalsCaprylatesFemaleMaleMiceMice, Inbred C57BLCaprylatesFluoridesFluorocarbonsperfluorooctanoic acidbioaccumulationfluorideFTOHhypoplasiaodontogenesisPFASPFOA

Identifiers

PMID42329147
PMCPMC13348020

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.