ArticleSports medicine (Auckland, N.Z.)2026
Systemic Degree of Perturbation of Plasma Markers Reveals Cumulative Biological Stress Across the Competitive Season in Professional Soccer Players.
Article in Sports medicine (Auckland, N.Z.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
backgroundFixture congestion has emerged as one of the defining challenges of modern professional soccer, exposing players to repeated high-intensity demands with limited opportunities for recovery. Such cumulative exposure taxes multiple physiological systems and may lead to sustained biological strain throughout the competitive season. However, the integrated systemic impact of congested schedules remains incompletely characterized.
objectiveWe aimed to characterize the systemic physiological impact of cumulative competitive load across a full professional soccer season using an integrated biomarker framework.
methodsIn this prospective longitudinal investigation, we employed the systemic degree of perturbation score, an adaptation of the molecular degree of perturbation, to circulating biochemical, hematological, and metabolic biomarkers obtained from professional soccer players across a full competitive season. Multi-dimensional analyses were employed to characterize systemic alterations associated with cumulative competitive load.
resultsA progressive increase in systemic perturbation was observed across the competitive season. The relative contribution of individual biomarkers shifted over time, with late-season phases characterized by more integrated muscular-inflammatory-metabolic profiles. Myoglobin and monocyte-related markers consistently contributed to systemic degree of perturbation values across competitive quarters, and network analyses demonstrated progressive changes in correlation architecture involving muscular, inflammatory, and metabolic mediators.
conclusionsThese results provide a comprehensive view of the physiological burden imposed by a professional soccer season and describe a progressive integration of muscular, inflammatory, and metabolic responses under cumulative competitive load. This integrated perspective supports the potential utility of biomarker-based monitoring frameworks for characterizing seasonal biological strain in elite athletes.
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