Evidence map›Paper›PMID 42329762›Full record

ArticleCell reports2026

Pancreatic α-cells integrate immune and neuronal stimuli for insulin secretion.

Kelly A Trimigliozzi, Sophia J Wiedemann, Giada Ostinelli, Leila Rachid, Hélène Méreau, Marianne Böni-Schnetzler, Guy A Rutter, Daniel T Meier, Marc Y Donath

Abstract read
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In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kelly A TrimigliozziDepartment of Biomedicine, University of Basel, Basel, Switzerland; Clinical Trial Unit, Cantonal Hospital Baden, Baden, Switzerland. Electronic address: k.trimigliozzi@unibas.ch.
Sophia J WiedemannDepartment of Biomedicine, University of Basel, Basel, Switzerland.
Giada OstinelliResearch Centre (CRCHUM) and University Hospital, University of Montreal, Montreal, QC, Canada.
Leila RachidDepartment of Biomedicine, University of Basel, Basel, Switzerland.
Hélène MéreauDepartment of Biomedicine, University of Basel, Basel, Switzerland.
Marianne Böni-SchnetzlerDepartment of Biomedicine, University of Basel, Basel, Switzerland.
Guy A RutterResearch Centre (CRCHUM) and University Hospital, University of Montreal, Montreal, QC, Canada; Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore; Research Institute of the McGill University Hospital Center, Montréal, QC, Canada.
Daniel T MeierDepartment of Biomedicine, University of Basel, Basel, Switzerland.
Marc Y DonathClinical Trial Unit, Cantonal Hospital Baden, Baden, Switzerland; Research Centre (CRCHUM) and University Hospital, University of Montreal, Montreal, QC, Canada. Electronic address: marc.donath@umontreal.ca.

Funding

Control of insulin secretion by mitochondrial fusionR01DK135268 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Brett A Kaufman, Scott Soleimanpour · 2023 to 2026
$2.4M
NIDDK NIH HHS R01 DK135268Wellcome Trust
6 · The paper itself

Abstract

Insulin secretion can be stimulated by immune and neuronal processes prior to a rise in blood glucose, exemplified by the cephalic phase of insulin response in the anticipation of food. Pancreatic α-cells prevent hypoglycemia by releasing glucagon. Here, we identified α-cells as critical mediators of IL-1β- and cholinergic agonist-driven insulin secretion. Cholinergic blockade prevented glucagon-stimulated insulin secretion in mice. Selective ablation of α-cells abolished cephalic phase insulin release. Islets from α-cell-deficient mice also failed to secrete insulin in response to IL-1β or muscarinic receptor activation. However, glucagon, acting on glucagon and GLP-1 receptors, rescued this insulin-stimulatory response. Mechanistically, intracellular Ca

Indexed as

Glucagon-Secreting CellsInsulin SecretionNeuronsAnimalsCalciumGlucagonGlucoseInsulinInterleukin-1betaMaleMiceMice, Inbred C57BLReceptors, MuscarinicCalciumGlucagonGlucoseInsulinInterleukin-1betaReceptors, Muscariniccephalic phaseCP: metabolismCP: neuroscienceglucagonIL-1βinsulinparasympathetic stimulation

Identifiers

PMID42329762
PMCPMC13643029

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.