ArticleImmunity2026
Analysis of West Nile disease convalescents identifies human monoclonal antibodies protective against West Nile and related orthoflaviviruses.
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Article in Immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3citing papers in PubMed
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Who cites it
3 citing papers in PubMed.
- Structural basis of diverse antibody recognition of conserved coronavirus spike S2 epitopes that contribute to protective immunity.bioRxiv : the preprint server for biology · 2026Article
- Dissociation kinetics and avidity gate SARS-CoV-2 neutralization by HR2 stem helix antibodies.bioRxiv : the preprint server for biology · 2026Article
- Underrecognized Tick-Borne Encephalitis in Serbia: Evidence from Patients with Suspected West Nile Virus Neuroinvasive Disease.Pathogens (Basel, Switzerland) · 2026Article
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Authors and funding
42 authors.
Tomás Cervantes RincónInstitute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
Tereza FrckovaInstitute of Experimental Biology, Faculty of Science, Masaryk University, Brno 62500, Czech Republic; Veterinary Research Institute, Brno 62100, Czech Republic.
Zaria I ContejeanStanford Biosciences, Stanford School of Medicine, Stanford, CA 94305, USA.
Jasmine CantergianiInstitute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
Kevin GroenInstitute of Medical Virology, University of Zurich, 8057 Zurich, Switzerland.
Benedetta CenaInstitute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
Simone G MoroInstitute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
Filippo BianchiniInstitute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
Luca SimonelliInstitute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
David JarrossayInstitute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
Silvia TosoliniInstitute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
Roger KuratliInstitute of Medical Virology, University of Zurich, 8057 Zurich, Switzerland.
Anna R E RobinsonStanford Biosciences, Stanford School of Medicine, Stanford, CA 94305, USA.
Monika CizkovaInstitute of Parasitology, Biology Centre of the Czech Academy of Sciences, České Budějovice 37005, Czech Republic; Faculty of Science, University of South Bohemia, České Budějovice 37005, Czech Republic.
Emily G NiejadlikLaboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, NY 10065, USA.
Jacques MoritzInstitute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
Roshan ThakurInstitute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
Zuzana KrátkaVeterinary Research Institute, Brno 62100, Czech Republic.
Dragana MijatovićDiagnostics and Laboratory Research Task Force, Balkan Association for Vector-Borne Diseases, Novi Sad 21000, Serbia; Department for Research & Monitoring of Rabies & Other Zoonoses, Pasteur Institute Novi Sad, Novi Sad 21000, Serbia.
Jasmina GrujićDiagnostics and Laboratory Research Task Force, Balkan Association for Vector-Borne Diseases, Novi Sad 21000, Serbia; Blood Transfusion Institute Vojvodina, Novi Sad 21000, Serbia; Faculty of Medicine in Novi Sad, University of Novi Sad, Novi Sad 21000, Serbia.
Jiri HoloubekInstitute of Experimental Biology, Faculty of Science, Masaryk University, Brno 62500, Czech Republic; Veterinary Research Institute, Brno 62100, Czech Republic; Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, České Budějovice 37005, Czech Republic.
Zorana Budakov-ObradovićBlood Transfusion Institute Vojvodina, Novi Sad 21000, Serbia; Faculty of Medicine in Novi Sad, University of Novi Sad, Novi Sad 21000, Serbia.
Jiri SalatInstitute of Experimental Biology, Faculty of Science, Masaryk University, Brno 62500, Czech Republic; Veterinary Research Institute, Brno 62100, Czech Republic; Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, České Budějovice 37005, Czech Republic.
Václav HönigVeterinary Research Institute, Brno 62100, Czech Republic; Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, České Budějovice 37005, Czech Republic.
Marija VranešDepartment for Transfusion Medicine, Clinical Center of Kragujevac, Kragujevac 34000, Serbia; Faculty of Medical Sciences, University of Kragujevac, Kragujevac 34000, Serbia.
Zvezdana LojpurClinic for Infectious Diseases, Clinical Center of Vojvodina, Novi Sad 21000, Serbia.
Dajana LendakFaculty of Medicine in Novi Sad, University of Novi Sad, Novi Sad 21000, Serbia; Clinic for Infectious Diseases, Clinical Center of Vojvodina, Novi Sad 21000, Serbia.
Siniša SevićFaculty of Medicine in Novi Sad, University of Novi Sad, Novi Sad 21000, Serbia; Clinic for Infectious Diseases, Clinical Center of Vojvodina, Novi Sad 21000, Serbia.
Monika BajčiFaculty of Medicine in Novi Sad, University of Novi Sad, Novi Sad 21000, Serbia; Clinic for Infectious Diseases, Clinical Center of Vojvodina, Novi Sad 21000, Serbia.
Lidija Popović-DragonjićDepartment of Infectious Diseases and Epidemiology, Faculty of Medicine Niš, University of Niš, Niš 18000, Serbia; Clinic for Infectology, University Clinical Center Niš, Niš 18000, Serbia; Clinical Medicine Task Force, Balkan Association for Vector-Borne Diseases, Novi Sad 21000, Serbia.
Biljana Popovska JovičićClinical Medicine Task Force, Balkan Association for Vector-Borne Diseases, Novi Sad 21000, Serbia; Department of Infectious Diseases, Faculty of Medical Sciences, University of Kragujevac, Kragujevac 34000, Serbia; University Clinical Centre Kragujevac, Kragujevac 34000, Serbia.
Jagoda GavrilovićDepartment of Infectious Diseases, Faculty of Medical Sciences, University of Kragujevac, Kragujevac 34000, Serbia; University Clinical Centre Kragujevac, Kragujevac 34000, Serbia.
Tania KapoorLaboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
Margaret R MacDonaldLaboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
Stylianos BournazosLaboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, NY 10065, USA.
Luca VaraniInstitute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
Martin PalusInstitute of Experimental Biology, Faculty of Science, Masaryk University, Brno 62500, Czech Republic; Veterinary Research Institute, Brno 62100, Czech Republic; Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, České Budějovice 37005, Czech Republic.
Benjamin G HaleInstitute of Medical Virology, University of Zurich, 8057 Zurich, Switzerland.
Pavle BanovićDiagnostics and Laboratory Research Task Force, Balkan Association for Vector-Borne Diseases, Novi Sad 21000, Serbia; Department of Prevention of Rabies and Other Infectious Diseases, Pasteur Institute Novi Sad, Novi Sad 21000, Serbia; Department of Microbiology with Parasitology and Immunology, Faculty of Medicine, University of Novi Sad, Novi Sad 21000, Serbia.
Daniel RuzekInstitute of Experimental Biology, Faculty of Science, Masaryk University, Brno 62500, Czech Republic; Veterinary Research Institute, Brno 62100, Czech Republic; Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, České Budějovice 37005, Czech Republic.
Christopher O BarnesStanford Biosciences, Stanford School of Medicine, Stanford, CA 94305, USA; Department of Biology, Stanford University, Stanford, CA 94305, USA; ChEM-H Institute, Stanford University, Stanford, CA 94305, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.
Davide F RobbianiInstitute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland. Electronic address: drobbiani@irb.usi.ch.
Funding
A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Clyde Smith · 2020 to 2026
$43.3MUnderstanding B cell memory in response to diverse virus infectionsU19AI111825 · NIAID · ROCKEFELLER UNIVERSITY · PI RAVETCH, JEFFREY VICTOR · 2014 to 2023
$26.0MUniversity of Washington Arboviral Research Network (UWARN)U01AI151698 · NIAID · UNIVERSITY OF WASHINGTON · PI Michael Gale, PETER MACGARR RABINOWITZ · 2020 to 2026
$13.3MVirology CoreP01AI138938 · NIAID · ROCKEFELLER UNIVERSITY · PI NUSSENZWEIG, MICHEL C · 2018 to 2022
$8.4MUnraveling yellow fever 17D vaccine attenuation: The role of type I interferon and innate immunityR01AI124690 · NIAID · ROCKEFELLER UNIVERSITY · PI Charles M Rice · 2016 to 2026
$8.3MMechanisms of antibody-dependent enhancement of SARS-CoV-2 infectionR01AI137276 · NIAID · ROCKEFELLER UNIVERSITY · PI Stylianos Bournazos · 2018 to 2026
$4.5MNIAID NIH HHS P01 AI138938NIAID NIH HHS R01 AI124690NIAID NIH HHS R01 AI137276NIAID NIH HHS U01 AI151698NIAID NIH HHS U19 AI111825NIGMS NIH HHS P30 GM133894
Abstract
West Nile virus (WNV) is a mosquito-borne pathogen of global concern that can cause fatal neuroinvasive disease, and no specific prophylaxis or treatment exists for infections by WNV and most related orthoflaviviruses. Here, we isolated and characterized antibodies from WNV convalescent individuals and report that neutralizing autoantibodies against type I interferons did not impair antiviral antibody development. Among the monoclonal antibodies with potent neutralizing activity against WNV that were identified, W010 targeted a distinct epitope within the envelope protein domain III (EDIII) and conferred both pre- and post-exposure protection in a murine WNV model, even when interferon signaling was impaired. A second protective antibody, W014, exhibited broad cross-neutralization of other pathogenic orthoflavivirus members, including Japanese encephalitis virus, Murray Valley encephalitis virus, Saint Louis encephalitis virus, and Usutu virus. These findings identify key neutralizing epitopes on WNV EDIII and provide candidates for the development of antibody-based interventions against encephalitic orthoflavivirus infections.
Indexed as
Antibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralFlavivirusWest Nile FeverWest Nile virusAnimalsDisease Models, AnimalEpitopesHumansMiceMosquito-Borne DiseasesViral Envelope ProteinsAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralEpitopesViral Envelope Proteinsautoantibodiesenvelope domain IIIJapanese encephalitis serocomplexneutralizing human monoclonal antibodiesorthoflavivirusestype I interferonWest Nile virus
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.