Evidence map›Paper›PMID 42331851›Full record

ReviewNPJ systems biology and applications2026

In silico models in oncology, neurology, and epidemiology: systems-level and multiscale perspectives.

Matteo Italia, José Garcia Otero, Juan Jiménez-Sánchez, Fabio Dercole, Juan Belmonte-Beitia

Abstract readReview
In one paragraph

Review in NPJ systems biology and applications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Matteo ItaliaDepartment of Electronic, Information, and Bioengineering, Politecnico di Milano, Milano, Italy.
José Garcia OteroMathematical Oncology Laboratory (MOLAB), Castilla-La Mancha Health Research Institute (IDISCAM), Ciudad Real, Spain.
Juan Jiménez-SánchezMathematical Oncology Laboratory (MOLAB), Castilla-La Mancha Health Research Institute (IDISCAM), Ciudad Real, Spain.
Fabio DercoleDepartment of Electronic, Information, and Bioengineering, Politecnico di Milano, Milano, Italy.
Juan Belmonte-BeitiaMathematical Oncology Laboratory (MOLAB), Castilla-La Mancha Health Research Institute (IDISCAM), Ciudad Real, Spain. juan.belmonte@uclm.es.

Funding

Junta de Comunidades de Castilla-La Mancha, Spain and European Regional Development Fund Grant No. SBPLY 23/180225/000041Ministerio de Ciencia e Innovación/Agencia Estatal de Investigación (AEI), Spain and European Regional Development Fund doi:10.13039/501100011033University of Castilla-La Mancha/FEDER (Applied Science Projects within the UCLM research programme) grant 2022-GRIN-34405
6 · The paper itself

Abstract

Computational medicine uses mathematical modelling, high-performance computing, and the availability of large-scale biomedical data to study multiscale complex diseases. This review synthesises recent developments in in silico oncology, neurology, and epidemiology, highlighting their shared methodological foundations in systems theory and complex networks. We discuss how combining mechanistic approaches with machine learning integrates heterogeneous data. Finally, we identify translation barriers and outline future directions like digital twins for predictive, personalised healthcare.

Indexed as

Computer SimulationMedical OncologyNeurologyComputational BiologyHumansMachine LearningSoft Computing

Identifiers

PMID42331851
PMCPMC13646278

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.