Evidence map›Paper›PMID 42332021›Full record

ArticleNature chemical biology2026

A ratiometric fluorescent reporter of mitochondrial sodium.

Koushambi Mitra, Soyoung Kim, Daphne Oettinger, Sanjeev Uthishtran, Qian Zhao, Aneesh Tazhe Veetil, Joseph R Ramirez, Hening Lin, Senthil Arumugam, Yamuna Krishnan

Abstract read
In one paragraph

Article in Nature chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Koushambi Mitra *Department of Chemistry, The University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-4325-453X
Soyoung Kim *Department of Chemistry, The University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-7681-106X
Daphne OettingerDepartment of Chemistry, The University of Chicago, Chicago, IL, USA.
Sanjeev UthishtranMonash Biomedicine Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton/Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0001-8538-3482
Qian ZhaoDepartment of Chemistry, The University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-2918-2077
Aneesh Tazhe VeetilDepartment of Chemistry, The University of Chicago, Chicago, IL, USA.
Joseph R RamirezDepartment of Chemistry, The University of Chicago, Chicago, IL, USA.
Hening LinDepartment of Chemistry, The University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-0255-2701
Senthil ArumugamMonash Biomedicine Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton/Melbourne, Victoria, Australia. senthil.arumugam@monash.edu.ORCID http://orcid.org/0000-0001-6733-4679
Yamuna KrishnanDepartment of Chemistry, The University of Chicago, Chicago, IL, USA. yamuna@uchicago.edu.ORCID http://orcid.org/0000-0001-5282-8852

Funding

Intracellular Electrophysiology: An electrochemical atlas of organellesDP1GM149751 · NIGMS · UNIVERSITY OF CHICAGO · PI KRISHNAN, YAMUNA · 2022 to 2025
$5.7M
Mechanism and function of intracellular sodium-proton exchangersR01GM147197 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI KRISHNAN, YAMUNA, MIRSHAHI, TOORAJ · 2022 to 2025
$2.4M
Calcium homeostasis in organellesR01NS112139 · NINDS · UNIVERSITY OF CHICAGO · PI KRISHNAN, YAMUNA · 2020 to 2024
$1.8M
NIGMS NIH HHS DP1 GM149751NIGMS NIH HHS R01 GM147197NINDS NIH HHS R01 NS112139U.S. Department of Health & Human Services | National Institutes of Health (NIH) DP1GM149751U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) 1R01GM147197-01U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) 1R01NS112139-01A1U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) 1R21NS114428-01
6 · The paper itself

Abstract

Cells cope with salt stress, hypoxia or elevated cytosolic Ca

Indexed as

Fluorescent DyesMitochondriaSodiumCalciumFibroblastsFluorescent Chemosensor CompoundsHumansSodium-Calcium ExchangerCalciumFluorescent Chemosensor CompoundsFluorescent DyesSodiumSodium-Calcium Exchanger

Identifiers

PMID42332021
PMCPMC13430436

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.