Molecular modelling of the adipokinetic hormone receptor from the stick insect Carausius morosus, and its endogenous agonist.

G E Jackson, H G Marco, M A Sani, F Separovic, G Gäde

Abstract read

In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

G E JacksonDepartment of Chemistry, University of Cape Town, Private Bag, Rondebosch, 7701, South Africa. graham.jackson@uct.ac.za.

H G MarcoDepartment of Biological Sciences, University of Cape Town, Private Bag, Rondebosch, 7701, South Africa.

M A SaniSchool of Chemistry, Bio21 Institute, University of Melbourne, Melbourne, VIC, 3010, Australia.

F SeparovicSchool of Chemistry, Bio21 Institute, University of Melbourne, Melbourne, VIC, 3010, Australia.

G GädeDepartment of Biological Sciences, University of Cape Town, Private Bag, Rondebosch, 7701, South Africa.

Funding

National Research Foundation of South Africa 109204 [IFR170221223270]National Research Foundation of South Africa 85768 [IFR13020116790]National Research Foundation of South Africa grant Nos 93450 and 85466

6 · The paper itself

Abstract

This study combines NMR spectroscopy, molecular dynamics (MD) simulations, and docking approaches to investigate the structure, dynamics, and receptor interactions of the decapeptide Carmo-HrTH-II from the stick insect Carausius morosus. NMR data indicate a flexible peptide that adopts a β-turn between Pro⁶ and Asn⁷, a feature that is also observed in MD simulations and may contribute to receptor recognition. Docking of Carmo-HrTH-II to a Carmo-AKHR homology model suggests a stable binding mode in which Phe

Indexed as

InsectaInsect HormonesInsect ProteinsModels, MolecularOligopeptidesPyrrolidonecarboxylic AcidAmino Acid SequenceAnimalsBinding SitesMolecular Docking SimulationMolecular Dynamics SimulationMolecular Sequence DataProtein Bindingadipokinetic hormoneInsect HormonesInsect ProteinsOligopeptidesPyrrolidonecarboxylic Acid

Identifiers

PMID42332141

DOI10.1038/s41598-026-53180-5

PMCPMC13572383

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.